Jianjun Zhang1, Ishwori B Dhakal, Xuemei Zhang, Anna E Prizment, Kristin E Anderson. 1. From the *Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health at IUPUI; †Melvin Bren Simon Cancer Center, Indiana University, Indianapolis, IN; ‡Department of Biostatistics, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR; §Department of Molecular Biology, College of Life Sciences, Hebei United University, Tangshan, China; ∥Division of Epidemiology and Community Health, School of Public Health, and ¶Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Abstract
OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.
OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS:Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.
Authors: Kristin E Anderson; Rashmi Sinha; Martin Kulldorff; Myron Gross; Nicholas P Lang; Cheryl Barber; Lisa Harnack; Eugene DiMagno; Robin Bliss; Fred F Kadlubar Journal: Mutat Res Date: 2002-09-30 Impact factor: 2.433
Authors: Olavi Ukkola; Eric Ravussin; Peter Jacobson; Louis Pérusse; Tuomo Rankinen; Matthias Tschöp; Mark L Heiman; Arthur S Leon; D C Rao; James S Skinner; Jack H Wilmore; Lars Sjöström; Claude Bouchard Journal: Obes Res Date: 2002-08
Authors: Joanne W Elena; Emily Steplowski; Kai Yu; Patricia Hartge; Geoffrey S Tobias; Michelle J Brotzman; Stephen J Chanock; Rachael Z Stolzenberg-Solomon; Alan A Arslan; H Bas Bueno-de-Mesquita; Kathy Helzlsouer; Eric J Jacobs; Andrea LaCroix; Gloria Petersen; Wei Zheng; Demetrius Albanes; Naomi E Allen; Laufey Amundadottir; Ying Bao; Heiner Boeing; Marie-Christine Boutron-Ruault; Julie E Buring; J Michael Gaziano; Edward L Giovannucci; Eric J Duell; Göran Hallmans; Barbara V Howard; David J Hunter; Amy Hutchinson; Kevin B Jacobs; Charles Kooperberg; Peter Kraft; Julie B Mendelsohn; Dominique S Michaud; Domenico Palli; Lawrence S Phillips; Kim Overvad; Alpa V Patel; Leah Sansbury; Xiao-Ou Shu; Michael S Simon; Nadia Slimani; Dimitrios Trichopoulos; Kala Visvanathan; Jarmo Virtamo; Brian M Wolpin; Anne Zeleniuch-Jacquotte; Charles S Fuchs; Robert N Hoover; Myron Gross Journal: Cancer Causes Control Date: 2012-10-31 Impact factor: 2.506
Authors: Y C Chagnon; J H Wilmore; I B Borecki; J Gagnon; L Pérusse; M Chagnon; G R Collier; A S Leon; J S Skinner; D C Rao; C Bouchard Journal: J Clin Endocrinol Metab Date: 2000-01 Impact factor: 5.958
Authors: Guillaume Onyeaghala; John Lane; Nathan Pankratz; Heather H Nelson; Bharat Thyagarajan; Bruce Walcheck; Kristin E Anderson; Anna E Prizment Journal: PLoS One Date: 2019-06-05 Impact factor: 3.240