BACKGROUND: Anxiety has been linked to initiation, maintenance and relapse of alcohol dependence. Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively. OBJECTIVES: This study tested the hypotheses that abstinent alcohol-dependent patients would show a disruption of synchrony in these circuits as measured by resting state functional MRI. METHODS: The study examined recently abstinent (n = 13), longer-term abstinent (n = 16) alcohol-dependent patients and healthy controls (n = 22). Resting-state synchrony (RSS) was examined in specific circuits, where degree of synchrony has been found to correlate with state anxiety levels in previous studies. RESULTS: Alcohol-dependent patients showed significantly elevated scores on anxiety and depression inventories compared with controls. No significant group differences in synchrony were observed between right amygdala and right ventromedial prefrontal cortex (vmPFC), between left amygdala and left vmPFC, or, after correction for multiple comparisons, right amygdala and dorsomedial prefrontal cortex (dmPFC). However, significantly decreased positive synchrony was found between left basolateral amygdala and left anterior insula, in patients relative to controls. CONCLUSION: Both early and longer-term abstinent alcohol-dependent patients showed increased anxiety levels relative to controls and altered resting state synchrony in circuits previously linked to state anxiety. Notably, the significant group differences in synchrony were in the opposite direction to our predictions based on the literature. These results may point to a lack of generalizability of models derived from young healthy homogeneous samples.
BACKGROUND: Anxiety has been linked to initiation, maintenance and relapse of alcohol dependence. Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively. OBJECTIVES: This study tested the hypotheses that abstinent alcohol-dependent patients would show a disruption of synchrony in these circuits as measured by resting state functional MRI. METHODS: The study examined recently abstinent (n = 13), longer-term abstinent (n = 16) alcohol-dependent patients and healthy controls (n = 22). Resting-state synchrony (RSS) was examined in specific circuits, where degree of synchrony has been found to correlate with state anxiety levels in previous studies. RESULTS: Alcohol-dependent patients showed significantly elevated scores on anxiety and depression inventories compared with controls. No significant group differences in synchrony were observed between right amygdala and right ventromedial prefrontal cortex (vmPFC), between left amygdala and left vmPFC, or, after correction for multiple comparisons, right amygdala and dorsomedial prefrontal cortex (dmPFC). However, significantly decreased positive synchrony was found between left basolateral amygdala and left anterior insula, in patients relative to controls. CONCLUSION: Both early and longer-term abstinent alcohol-dependent patients showed increased anxiety levels relative to controls and altered resting state synchrony in circuits previously linked to state anxiety. Notably, the significant group differences in synchrony were in the opposite direction to our predictions based on the literature. These results may point to a lack of generalizability of models derived from young healthy homogeneous samples.
Authors: T Schulte; Y-C Jung; E V Sullivan; A Pfefferbaum; M Serventi; E M Müller-Oehring Journal: Brain Imaging Behav Date: 2017-12 Impact factor: 3.978
Authors: Xi Zhu; Nisha Dutta; Sarah G Helton; Melanie Schwandt; Jia Yan; Colin A Hodgkinson; Carlos R Cortes; Mike Kerich; Samuel Hall; Hui Sun; Monte Phillips; Reza Momenan; Falk W Lohoff Journal: Hum Brain Mapp Date: 2015-09-14 Impact factor: 5.038
Authors: Elizabeth A Flook; Joseph R Luchsinger; Marisa M Silveri; Danny G Winder; Margaret M Benningfield; Jennifer Urbano Blackford Journal: Addict Biol Date: 2020-01-28 Impact factor: 4.280
Authors: A Benjamin Srivastava; Juan Sanchez-Peña; Frances R Levin; John J Mariani; Gaurav H Patel; Nasir H Naqvi Journal: Alcohol Clin Exp Res Date: 2021-08-02 Impact factor: 3.928