OBJECTIVE: To expand the adverse events associated with metronidazole to include nonconvulsive status epilepticus (NCSE). DESIGN: Observational single case report of a rare association. SETTING: Hospitalized lung transplant recipient treated with metronidazole for prevention of infection. PATIENT: A 56-year-old man with systemic symptoms, peripheral neuropathy, generalized seizure, and a subsequent acute deterioration of mental status due to NCSE. INTERVENTIONS: Administration of midazolam was successful in terminating status epilepticus. MAIN OUTCOME MEASURES: Abrupt termination of NCSE was evident on continuous bedside electroencephalogam associated with clinical resolution of mental status. RESULTS: Recovery occurred from NCSE eventually deteriorating to a fatal outcome. CONCLUSIONS: Metronidazole may be associated with successfully treated NCSE.
OBJECTIVE: To expand the adverse events associated with metronidazole to include nonconvulsive status epilepticus (NCSE). DESIGN: Observational single case report of a rare association. SETTING: Hospitalized lung transplant recipient treated with metronidazole for prevention of infection. PATIENT: A 56-year-old man with systemic symptoms, peripheral neuropathy, generalized seizure, and a subsequent acute deterioration of mental status due to NCSE. INTERVENTIONS: Administration of midazolam was successful in terminating status epilepticus. MAIN OUTCOME MEASURES: Abrupt termination of NCSE was evident on continuous bedside electroencephalogam associated with clinical resolution of mental status. RESULTS: Recovery occurred from NCSE eventually deteriorating to a fatal outcome. CONCLUSIONS:Metronidazole may be associated with successfully treated NCSE.
Entities:
Keywords:
EEG; encephalopathy; metronidazole; nonconvulsive status epilepticus; organ transplant
Authors: H Treede; H Reichenspurner; B M Meiser; F Kur; H Fürst; C Vogelmeier; J Briegel; B Reichart Journal: Transplant Proc Date: 2001 Feb-Mar Impact factor: 1.066
Authors: M Goyal; E Versnick; P Tuite; J S Cyr; W Kucharczyk; W Montanera; R Willinsky; D Mikulis Journal: AJNR Am J Neuroradiol Date: 2000 Jun-Jul Impact factor: 3.825
Authors: Lorenzo Ricci; Francesco Motolese; Mario Tombini; Jacopo Lanzone; Roberta Rea; Francesco Di Matteo; Vincenzo Di Lazzaro; Giovanni Assenza Journal: Brain Sci Date: 2020-04-10