OBJECTIVE: The relationship between cardiorespiratory fitness (CRF) and metabolic syndrome (MetS) is well known, although the extent to which body weight may act as a confounder or mediator in this relationship is uncertain. The aim of this study was to examine whether the association between CRF and cardiometabolic risk factors is mediated by BMI. RESEARCH DESIGN AND METHODS: A cross-sectional study including 1,158 schoolchildren aged 8-11 years from the province of Cuenca, Spain, was undertaken. We measured height, weight, waist circumference (WC), blood pressure, fasting plasma lipid profile and insulin, and CRF (20-m shuttle run test). A validated cardiometabolic risk index was estimated by summing standardized z scores of WC, log triglyceride-to-HDL cholesterol ratio (TG/HDL-c), mean arterial pressure (MAP), and log fasting insulin. To assess whether the association between CRF and cardiometabolic risk was mediated by BMI, linear regression models were fitted according to Baron and Kenny procedures for mediation analysis. RESULTS: In girls, BMI acts as a full mediator in the relationship between CRF and cardiometabolic risk factors, with the exception of log TG/HDL-c ratio. In boys, BMI acts as a full mediator in the relationship between CRF and both log TG/HDL-c ratio and MAP, and as a partial mediator in the relationship between CRF and cardiometabolic risk factors. CONCLUSIONS: BMI mediates the association between CRF and MetS in schoolchildren. Overall, good levels of CRF are associated with lower cardiometabolic risk, particularly when accompanied by weight reduction.
OBJECTIVE: The relationship between cardiorespiratory fitness (CRF) and metabolic syndrome (MetS) is well known, although the extent to which body weight may act as a confounder or mediator in this relationship is uncertain. The aim of this study was to examine whether the association between CRF and cardiometabolic risk factors is mediated by BMI. RESEARCH DESIGN AND METHODS: A cross-sectional study including 1,158 schoolchildren aged 8-11 years from the province of Cuenca, Spain, was undertaken. We measured height, weight, waist circumference (WC), blood pressure, fasting plasma lipid profile and insulin, and CRF (20-m shuttle run test). A validated cardiometabolic risk index was estimated by summing standardized z scores of WC, log triglyceride-to-HDL cholesterol ratio (TG/HDL-c), mean arterial pressure (MAP), and log fasting insulin. To assess whether the association between CRF and cardiometabolic risk was mediated by BMI, linear regression models were fitted according to Baron and Kenny procedures for mediation analysis. RESULTS: In girls, BMI acts as a full mediator in the relationship between CRF and cardiometabolic risk factors, with the exception of log TG/HDL-c ratio. In boys, BMI acts as a full mediator in the relationship between CRF and both log TG/HDL-c ratio and MAP, and as a partial mediator in the relationship between CRF and cardiometabolic risk factors. CONCLUSIONS: BMI mediates the association between CRF and MetS in schoolchildren. Overall, good levels of CRF are associated with lower cardiometabolic risk, particularly when accompanied by weight reduction.
Authors: Ana Díez-Fernández; Mairena Sánchez-López; José Antonio Nieto; Alberto González-García; José Miota-Ibarra; Ignacio Ortiz-Galeano; Vicente Martínez-Vizcaíno Journal: Hypertens Res Date: 2017-01-12 Impact factor: 3.872
Authors: Pedro Delgado-Floody; Miguel Espinoza-Silva; Felipe García-Pinillos; Pedro Latorre-Román Journal: Eur J Pediatr Date: 2018-04-21 Impact factor: 3.183
Authors: Rosangela A Hoshi; Yanyan Liu; Mohit Jain; Daniel I Chasman; Olga V Demler; Samia Mora; Heike Luttmann-Gibson; Saumya Tiwari; Franco Giulianini; Allen M Andres; Jeramie D Watrous; Nancy R Cook; Karen H Costenbader; Olivia I Okereke; Paul M Ridker; JoAnn E Manson; I-Min Lee; Manickavasagar Vinayagamoorthy; Susan Cheng; Trisha Copeland Journal: Circ Res Date: 2022-07-19 Impact factor: 23.213
Authors: Diego Augusto Santos Silva; Justin J Lang; Joel D Barnes; Grant R Tomkinson; Mark S Tremblay Journal: PLoS One Date: 2018-08-01 Impact factor: 3.240