Literature DB >> 2419807

Simultaneous release of several tachykinins and calcitonin gene-related peptide from rat spinal cord slices.

A Saria, R Gamse, J Petermann, J A Fischer, E Theodorsson-Norheim, J M Lundberg.   

Abstract

Superfusion of slices of the dorsal half of rat spinal cord in vitro with 10 microM capsaicin or 60 mM potassium lead to the simultaneous release of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivities (LI). The ratio between capsaicin-stimulated and basal release was higher for CGRP-LI than for SP-LI, indicating that relatively more CGRP is released from sensory nerves, whereas SP is not only released from afferent neurons. High-performance liquid chromatography of NKA-LI revealed several immunoreactive components. One major peak had the retention time of synthetic NKA. A second peak eluted close to the position of synthetic eledoisin. In conclusion, capsaicin releases several bioactive peptides from sensory neurons which may mediate the acute algetic effect of chemical irritants.

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Year:  1986        PMID： 2419807     DOI： 10.1016/0304-3940(86)90376-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  26 in total

1.  Ultrastructural studies on calcitonin gene-related peptide-, tachykinins- and somatostatin-immunoreactive neurones in rat dorsal root ganglia: evidence for the colocalization of different peptides in single secretory granules.

Authors:  A Merighi; J M Polak; S J Gibson; S Gulbenkian; K L Valentino; S M Peirone
Journal:  Cell Tissue Res       Date:  1988-10       Impact factor: 5.249

2.  Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.

Authors:  P Alm; L M Lundberg
Journal:  Cell Tissue Res       Date:  1988       Impact factor: 5.249

3.  Reduced numbers of calcitonin gene-related peptide-(CGRP-) and tachykinin-immunoreactive sensory neurones associated with greater enkephalin immunoreactivity in the dorsal horn of a mutant rat with hereditary sensory neuropathy.

Authors:  S Kar; S J Gibson; F Scaravilli; J M Jacobs; V R Aber; J M Polak
Journal:  Cell Tissue Res       Date:  1989-02       Impact factor: 5.249

4.  Tachykinins and calcitonin gene-related peptide: co-existence in sensory nerves of the nasal mucosa and effects on blood flow.

Authors:  P Stjärne; L Lundblad; A Anggård; T Hökfelt; J M Lundberg
Journal:  Cell Tissue Res       Date:  1989-06       Impact factor: 5.249

5.  Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter.

Authors:  R Amann; G Skofitsch; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000

6.  Effect of three animal models of inflammation on nerve fibres in the synovium.

Authors:  P I Mapp; D A Walsh; N E Garrett; B L Kidd; S C Cruwys; J M Polak; D R Blake
Journal:  Ann Rheum Dis       Date:  1994-04       Impact factor: 19.103

7.  Effects of capsaicin desensitization on the stimulatory effect of kinins, prostaglandins, biogenic amines and various drugs in guinea-pig isolated atria.

Authors:  A Bernoussi; F Rioux
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

8.  Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.

Authors:  C M Stubbs; G J Waldron; H E Connor; W Feniuk
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Capsaicin and nicotine-sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis.

Authors:  P Stjärne; L Lundblad; J M Lundberg; A Anggård
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

10.  Calcitonin gene-related peptide (CGRP) activates human neutrophils--inhibition by chemotactic peptide antagonist BOC-MLP.

Authors:  J Richter; R Andersson; L Edvinsson; U Gullberg
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397
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