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Literature DB >> 24197469

Kinetic studies of peptide bond formation. Effect of chloramphenicol.

Abstract

There might be an undetermined order in the interaction of the substrates with the ribosomes in the reaction of CACCA-Leu-Ac with puromycin to form Ac-Leu-puromycin and CACCA ('fragment reaction'). Km 0°=6×10(-4) M for the puromycin · ribosome interaction. Chloramphenicol totally blocks the 'fragment reaction' as a consequence of a single interaction with the ribosome of Kd 0°=2.2×10(-6) M. The inhibition by chloramphenicol of the 'fragment reaction' is mixed competitive for puromycin.

Entities: Chemical

Year: 1973 PMID： 24197469 DOI： 10.1007/BF00357584

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

16 in total

1. Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes.

Authors: M L. Celma; R E. Monro; D Vazquez
Journal: FEBS Lett Date: 1970-02-16 Impact factor: 4.124

2. Studies on transfer ribonucleic acid-ribosome complexes. XIX. Effect of antibiotics on peptidyl puromycin synthesis on polyribosoms from Escherichia coli.

Authors: S Pestka
Journal: J Biol Chem Date: 1972-07-25 Impact factor: 5.157

3. The peptidyl transferase activity of ribosomes.

Authors: R E Monro; T Staehelin; M L Celma; D Vazquez
Journal: Cold Spring Harb Symp Quant Biol Date: 1969

4. Some requirements and characteristics of the fragment reaction.

Authors: E Silverstein
Journal: Cold Spring Harb Symp Quant Biol Date: 1969

5. Ribosome-catalyzed ester formation.

Authors: S Fahnestock; H Neumann; V Shashoua; A Rich
Journal: Biochemistry Date: 1970-06-09 Impact factor: 3.162

6. Inhibition by sparsomycin and other antibiotics of the puromycin-induced release of polypeptide from ribosomes.

Authors: I H Goldberg; K Mitsugi
Journal: Biochemistry Date: 1967-02 Impact factor: 3.162

7. Transesterification by peptidyl transferase.

Authors: E Scolnick; G Milman; M Rosman; T Caskey
Journal: Nature Date: 1970-01-10 Impact factor: 49.962

8. The behaviour of acetylphenylalanyl soluble ribonucleic acid in polyphenylalanine synthesis.

Authors: A L Haenni; F Chapeville
Journal: Biochim Biophys Acta Date: 1966-01-18

9. The function of 80 S ribosomal subunits and effects of some antibiotics.

Authors: D Vazquez; E Battaner; R Neth; G Heller; R E Monro
Journal: Cold Spring Harb Symp Quant Biol Date: 1969

10. Substrate- and antibiotic-binding sites at the peptidyl-transferase centre of Escherichia coli ribosomes. Studies on the chloramphenicol. lincomycin and erythromycin sites.

Authors: R Fernandez-Munoz; R E Monro; R Torres-Pinedo; D Vazquez
Journal: Eur J Biochem Date: 1971-11-11

4 in total

1. A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel.

Authors: Katherine S Long; Bo T Porse
Journal: Nucleic Acids Res Date: 2003-12-15 Impact factor: 16.971

2. Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action.

Authors: Maria A Xaplanteri; Athanasios Andreou; George P Dinos; Dimitrios L Kalpaxis
Journal: Nucleic Acids Res Date: 2003-09-01 Impact factor: 16.971

Review 3. Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions.

Authors: George P Dinos; Constantinos M Athanassopoulos; Dionissia A Missiri; Panagiota C Giannopoulou; Ioannis A Vlachogiannis; Georgios E Papadopoulos; Dionissios Papaioannou; Dimitrios L Kalpaxis
Journal: Antibiotics (Basel) Date: 2016-06-03

4. Incorporation of Chloramphenicol Loaded Hydroxyapatite Nanoparticles into Polylactide.

Authors: Manuel Rivas; Marc Pelechà; Lourdes Franco; Pau Turon; Carlos Alemán; Luis J Del Valle; Jordi Puiggalí
Journal: Int J Mol Sci Date: 2019-10-11 Impact factor: 5.923

4 in total