Literature DB >> 24196317

Mammalian cell line developments in speed and efficiency.

Scott Estes1, Mark Melville.   

Abstract

Mammalian cell expression systems are the dominant tool today for producing complex biotherapeutic proteins. In this chapter, we discuss the basis for this dominance, and further explore why the Chinese hamster ovary (CHO) cell line has become the prevalent choice of hosts to produce most recombinant biologics. Furthermore, we explore some of the innovations that are currently in development to improve the CHO cell platform, from cell line specific technologies to overarching technologies that are designed to improve the overall workflow of bioprocess development.

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Year:  2014        PMID： 24196317     DOI： 10.1007/10_2013_260

Source DB:  PubMed          Journal:  Adv Biochem Eng Biotechnol        ISSN： 0724-6145            Impact factor:   2.635


  9 in total

1.  Transient Transfection and Expression of Eukaryotic Membrane Proteins in Expi293F Cells and Their Screening on a Small Scale: Application for Structural Studies.

Authors:  Ganna O Krasnoselska; Maud Dumoux; Nadisha Gamage; Harish Cheruvara; James Birch; Andrew Quigley; Raymond J Owens
Journal:  Methods Mol Biol       Date:  2021

2.  Early integration of Design of Experiment (DOE) and multivariate statistics identifies feeding regimens suitable for CHO cell line development and screening.

Authors:  Alessandro Mora; Bernard Nabiswa; Yuanyuan Duan; Sheng Zhang; Gerald Carson; Seongkyu Yoon
Journal:  Cytotechnology       Date:  2019-11-09       Impact factor: 2.058

Review 3.  Expression of mammalian proteins for diagnostics and therapeutics: a review.

Authors:  Jacqueline Kar Kei Mark; Crystale Siew Ying Lim; Fazlina Nordin; Gee Jun Tye
Journal:  Mol Biol Rep       Date:  2022-06-08       Impact factor: 2.742

Review 4.  Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.

Authors:  Marsela Jorgolli; Tanner Nevill; Aaron Winters; Irwin Chen; Su Chong; Fen-Fen Lin; Marissa Mock; Ching Chen; Kim Le; Christopher Tan; Philip Jess; Han Xu; Agi Hamburger; Jennitte Stevens; Trent Munro; Ming Wu; Philip Tagari; Les P Miranda
Journal:  Biotechnol Bioeng       Date:  2019-06-24       Impact factor: 4.530

5.  In-Solution IgG Titer Determination in Fermentation Broth Using Affibodies and Flow-Induced Dispersion Analysis.

Authors:  Morten E Pedersen; Jesper Østergaard; Henrik Jensen
Journal:  ACS Omega       Date:  2020-04-28

Review 6.  Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors.

Authors:  Ali Mobasheri; Stephen M Richardson
Journal:  Neurosurg Clin N Am       Date:  2020-01       Impact factor: 2.509

7.  Production of Recombinant Transmembrane Proteins from Mammalian Cells for Biochemical and Structural Analyses.

Authors:  Robbins Puthenveetil; Chul-Jin Lee; Anirban Banerjee
Journal:  Curr Protoc Cell Biol       Date:  2020-06

Review 8.  Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives.

Authors:  Jennifer Dumont; Don Euwart; Baisong Mei; Scott Estes; Rashmi Kshirsagar
Journal:  Crit Rev Biotechnol       Date:  2015-09-18       Impact factor: 8.429

9.  Knocking out Ornithine Decarboxylase Antizyme 1 (OAZ1) Improves Recombinant Protein Expression in the HEK293 Cell Line.

Authors:  Laura Abaandou; Joseph Shiloach
Journal:  Med Sci (Basel)       Date:  2018-06-08
  9 in total

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