Literature DB >> 24194193

Fluorescence and circular dichroism studies on binding and conformational aspects of an anti-leukemic drug with DNA.

Ashwini H Hegde1, J Seetharamappa.   

Abstract

In the present study, we have explored the mode of binding of an anti-leukemic drug, imatinib (IMT) mesylate with DNA and resulting conformational changes in DNA double helix. UV-Vis absorption, fluorescence and circular dichroism spectroscopic techniques were employed to study these interactions. Spectroscopic results revealed that the intercalation was the primary mode of interaction between IMT and DNA. The binding constant value of 6.62 × 10(3 )M(-1) indicated the moderate interaction between IMT and DNA. Melting temperature of DNA increased from 75 to 80 °C upon interaction with IMT.

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Year:  2013        PMID： 24194193     DOI： 10.1007/s11033-013-2838-2

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  15 in total

1.  Fluorescence energy transfer between Acridine Orange and Safranine T and its application in the determination of DNA.

Authors:  Y Cao; X He; Z Gao; L Peng
Journal:  Talanta       Date:  1999-06-14       Impact factor: 6.057

2.  Multi-spectroscopic methods combined with molecular modeling dissect the interaction mechanisms of ractopamine and calf thymus DNA.

Authors:  Jun Chai; Juyuan Wang; Qifei Xu; Fang Hao; Rutao Liu
Journal:  Mol Biosyst       Date:  2012-05-18

3.  FTIR and circular dichroism spectroscopic study of interaction of 5-fluorouracil with DNA.

Authors:  Deepak K Jangir; Sonika Charak; Ranjana Mehrotra; Suman Kundu
Journal:  J Photochem Photobiol B       Date:  2011-08-18       Impact factor: 6.252

4.  Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.

Authors:  Ashwini H Hegde; S N Prashanth; J Seetharamappa
Journal:  J Pharm Biomed Anal       Date:  2012-02-02       Impact factor: 3.935

5.  Resveratrol, genistein, and curcumin bind bovine serum albumin.

Authors:  P Bourassa; C D Kanakis; P Tarantilis; M G Pollissiou; H A Tajmir-Riahi
Journal:  J Phys Chem B       Date:  2010-03-11       Impact factor: 2.991

6.  Thermodynamics of protein association reactions: forces contributing to stability.

Authors:  P D Ross; S Subramanian
Journal:  Biochemistry       Date:  1981-05-26       Impact factor: 3.162

7.  Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.

Authors:  Chunyu Qiao; Shuyun Bi; Ying Sun; Daqian Song; Hanqi Zhang; Weihong Zhou
Journal:  Spectrochim Acta A Mol Biomol Spectrosc       Date:  2007-07-31       Impact factor: 4.098

8.  Spectroscopic and electrochemical studies of DNA breakage induced by dopamine and copper ion.

Authors:  Jun Liu; Qingwen Li; Yadong Yu; Xiang Fang
Journal:  Anal Sci       Date:  2003-08       Impact factor: 2.081

9.  In vitro study of DNA interaction with clodinafop-propargyl herbicide.

Authors:  Soheila Kashanian; Soyebeh Askari; Farhad Ahmadi; Kobra Omidfar; Sirous Ghobadi; Fereshteh Abasi Tarighat
Journal:  DNA Cell Biol       Date:  2008-10       Impact factor: 3.311

10.  Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: mode and specificity of binding.

Authors:  S Satyanarayana; J C Dabrowiak; J B Chaires
Journal:  Biochemistry       Date:  1993-03-16       Impact factor: 3.162
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  3 in total

1.  Spiropyran as a potential molecular diagnostic tool for double-stranded RNA detection.

Authors:  Ahsan Ausaf Ali; Minjeong Kang; Raisa Kharbash; Yoosik Kim
Journal:  BMC Biomed Eng       Date:  2019-03-18

2.  Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents.

Authors:  Minjeong Kang; Raisa Kharbash; Ja Min Byun; Jaemin Jeon; Ahsan Ausaf Ali; Doyeong Ku; Jimin Yoon; Yongsuk Ku; Jooyeon Sohn; Seung-Jae V Lee; Dong-Yeop Shin; Youngil Koh; Sung-Soo Yoon; Junshik Hong; Yoosik Kim
Journal:  Mol Ther Nucleic Acids       Date:  2022-07-21       Impact factor: 10.183

Review 3.  Intrinsically Fluorescent Anti-Cancer Drugs.

Authors:  Md Lutful Kabir; Feng Wang; Andrew H A Clayton
Journal:  Biology (Basel)       Date:  2022-07-28
  3 in total

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