Relationship of amino acid sequence to immunological activity - syntheses and structure-activity relationships of thymosinβ 4 family.

Four peptides related to thymosinβ 4 family and its six fragments were synthesized by the solution method. Among them, the four peptides related to thymosinβ 4 family and its two fragments were found to have restoring activity on the impaired blastogenic response of T-lymphocytes isolated from uremic patients, but the other four fragments had no effect. Studies on the structureactivity relationships suggest that the tricosapeptide moiety corresponding to amino acids 16-38 of thymosinβ 4 is found to be an important moiety on impaired immunological deficiency.