X-P Guo1, Y Wang, H Zhao, S-D Song, J Zhou, Y Han. 1. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
Abstract
OBJECTIVES: To investigate the relationship of the MTHFR polymorphisms (C677T) and the risk of CRC by meta-analysis. METHODS: Relevant literatures concerning the association between the MTHFR C677T polymorphism and the risk of CRC were searched using the electronic database PubMed, EMBASE, Cochrane and China National Knowledge Infrastructure (CNKI). Odds ratio (ORs) and 95 % confidence intervals (CIs) were determined to assess the gene-disease association using fixed or random effect models, according to the heterogeneity among included studies. RESULTS: The study shows that the MTHFR 677 TT homozygous genotype significantly decreases the risk of CRC in Asians (TT vs. CC: OR = 0.82, 95 % CI 0.73-0.92; TT vs. CT: OR = 0.84, 95 % CI 0.75-0.94; TT vs. CC+TT: OR = 0.83, 95 % CI 0.75-0.93). CONCLUSION: This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of CRC in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to CRC susceptibility.
OBJECTIVES: To investigate the relationship of the MTHFR polymorphisms (C677T) and the risk of CRC by meta-analysis. METHODS: Relevant literatures concerning the association between the MTHFRC677T polymorphism and the risk of CRC were searched using the electronic database PubMed, EMBASE, Cochrane and China National Knowledge Infrastructure (CNKI). Odds ratio (ORs) and 95 % confidence intervals (CIs) were determined to assess the gene-disease association using fixed or random effect models, according to the heterogeneity among included studies. RESULTS: The study shows that the MTHFR 677 TT homozygous genotype significantly decreases the risk of CRC in Asians (TT vs. CC: OR = 0.82, 95 % CI 0.73-0.92; TT vs. CT: OR = 0.84, 95 % CI 0.75-0.94; TT vs. CC+TT: OR = 0.83, 95 % CI 0.75-0.93). CONCLUSION: This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of CRC in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to CRC susceptibility.
Authors: Barbara Pardini; Rajiv Kumar; Alessio Naccarati; Rashmi B Prasad; Asta Forsti; Veronika Polakova; Ludmila Vodickova; Jan Novotny; Kari Hemminki; Pavel Vodicka Journal: Mutat Res Date: 2011-01-04 Impact factor: 2.433
Authors: Sunil Chandy; M N Sadananda Adiga; N Ramachandra; S Krishnamoorthy; Girija Ramaswamy; H S Savithri; Lakshmi Krishnamoorthy Journal: Indian J Med Res Date: 2010-05 Impact factor: 2.375