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Literature DB >> 24192987

Modelling amino acid metabolism.

Abstract

This article briefly summarises various aspects of building a model, before reviewing some models of protein turnover, the metabolism of selected amino acids, and urea synthesis in human subjects. Some software for use in modelling is noted. An Appendix lists terms with descriptions and definitions, which are often employed in modelling.

Entities: Chemical Species

Year: 1992 PMID： 24192987 DOI： 10.1007/BF00806006

Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520

27 in total

1. Study of the relationship between estimates of enzyme kinetic parameters.

Authors: K Wang; R I Kitney; J W Seakins; M Hjelm
Journal: J Theor Biol Date: 1992-04-21 Impact factor: 2.691

2. Detection of heterozygotes for phenylketonuria. Total body phenylalanine clearance and concentrations of phenylalanine and tyrosine in the plasms of fasting subjects compared.

Authors: R Jagenburg; C G Regårdh; S Rödjer
Journal: Clin Chem Date: 1977-09 Impact factor: 8.327

3. The urea cycle in the Rett syndrome.

Authors: S Thomas; V Oberholzer; J Wilson; M Hjelm
Journal: Brain Dev Date: 1990 Impact factor: 1.961

4. Determination of the rate of urea synthesis from serial measurements of plasma urea concentration after an alanine load: theoretical and methodological aspects.

Authors: D Geiseler; J D Kay; V G Oberholzer; J W Seakins; M Hjelm
Journal: Clin Sci (Lond) Date: 1985-02 Impact factor: 6.124

5. Optimal design of multioutput sampling schedules--software and applications to endocrine-metabolic and pharmacokinetic models.

Authors: C Cobelli; A Ruggeri; J J Distefano; E M Landaw
Journal: IEEE Trans Biomed Eng Date: 1985-04 Impact factor: 4.538

Modelling amino acid metabolism.

1. Study of the relationship between estimates of enzyme kinetic parameters.

2. Detection of heterozygotes for phenylketonuria. Total body phenylalanine clearance and concentrations of phenylalanine and tyrosine in the plasms of fasting subjects compared.

3. The urea cycle in the Rett syndrome.

4. Determination of the rate of urea synthesis from serial measurements of plasma urea concentration after an alanine load: theoretical and methodological aspects.

5. Optimal design of multioutput sampling schedules--software and applications to endocrine-metabolic and pharmacokinetic models.

6. Validation of simple and complex models in physiology and medicine.

7. 1987 McCollum award lecture. Kinetics of human amino acid metabolism: nutritional implications and some lessons.

8. Computer model of the metabolism of phenylalanine in normal subjects and in patients with phenylketonuria.

9. Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine.

10. Compartmental model of leucine kinetics in humans.

1. Interpretation of amino acid patterns in mammalian species.