Literature DB >> 24192906

Synthesis of S-farnesyl-L-cysteine methylester and purification by HPLC.

M Liakopoulou-Kyriakides1, T Choli-Papadopoulou.   

Abstract

S-trans, trans-farnesyl-L-cysteine methylester, a post translational modified amino acid, was synthesized from farnesyl bromide and L-cysteine methylester hydrochloride salt in the presence of triethylamine. Its purification as well as separation from the other isomers by HPLC on RP Vydac C4 and C8 columns are reported here.

Entities:  

Year:  1992        PMID： 24192906     DOI： 10.1007/BF00805949

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  8 in total

1.  Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.

Authors:  R Betz; J W Crabb; H E Meyer; R Wittig; W Duntze
Journal:  J Biol Chem       Date:  1987-01-15       Impact factor: 5.157

2.  Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides.

Authors:  Y Kamiya; A Sakurai; S Tamura; N Takahashi
Journal:  Biochem Biophys Res Commun       Date:  1978-08-14       Impact factor: 3.575

3.  Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

Authors:  R J Anderegg; R Betz; S A Carr; J W Crabb; W Duntze
Journal:  J Biol Chem       Date:  1988-12-05       Impact factor: 5.157

Review 4.  Fatty acylated proteins as components of intracellular signaling pathways.

Authors:  G James; E N Olson
Journal:  Biochemistry       Date:  1990-03-20       Impact factor: 3.162

5.  All ras proteins are polyisoprenylated but only some are palmitoylated.

Authors:  J F Hancock; A I Magee; J E Childs; C J Marshall
Journal:  Cell       Date:  1989-06-30       Impact factor: 41.582

6.  Posttranslational modification of ras proteins: detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification.

Authors:  F Tamanoi; E C Hsueh; L E Goodman; A R Cobitz; R J Detrick; W R Brown; A Fujiyama
Journal:  J Cell Biochem       Date:  1988-03       Impact factor: 4.429

7.  Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

Authors:  S Clarke; J P Vogel; R J Deschenes; J Stock
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

8.  Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

Authors:  L Gutierrez; A I Magee; C J Marshall; J F Hancock
Journal:  EMBO J       Date:  1989-04       Impact factor: 11.598
  8 in total

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