Petronella G Pieper1, Ali Balci, Jan G Aarnoudse, Marlies A M Kampman, Krystyna M Sollie, Henk Groen, Barbara J M Mulder, Martijn A Oudijk, Jolien W Roos-Hesselink, Jerome Cornette, Arie P J van Dijk, Marc E Spaanderman, Willem Drenthen, Dirk J van Veldhuisen. 1. Departments of Cardiology (P.G.P., A.B., M.A.M.K., W.D., D.J.v.V.), Obstetrics (J.G.A., K.M.S.), and Epidemiology (H.G.), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, The Netherlands (A.B., M.A.M.K.); Department of Cardiology, Isala, Zwolle, The Netherlands (A.B.); Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands (B.J.M.M.); Department of Obstetrics, University Medical Centre Utrecht, University of Utrecht, Utrecht, The Netherlands (M.A.O.); Departments of Cardiology (J.W.R.-H.) and Obstetrics (J.C.), Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands; and Departments of Cardiology (A.P.J.v.D.) and Obstetrics (M.E.S.), Radboud University Nijmegen Medical Centre, Radboud University Nijmegen, Nijmegen, The Netherlands.
Abstract
BACKGROUND: Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS: We performed a prospective multicenter cohort study of pregnant women with CHD and healthy pregnant women. We compared clinical, laboratory, echocardiographic, and uteroplacental Doppler flow (UDF) parameters at 20 and 32 weeks gestation, and pregnancy outcome. We related cardiovascular parameters to UDF parameters and pregnancy outcome in women with CHD. We included 209 women with CHD and 70 healthy women. Cardiovascular parameters (N-terminal pro-B-type natriuretic peptide, left and right ventricular function) differed between both groups. UDF parameters were impaired in CHD women (umbilical artery pulsatility and resistance index at 32 weeks in CHD versus healthy women, P=0.0085 and P=0.017). The following cardiovascular parameters prepregnancy and at 20 weeks gestation were associated with UDF (umbilical artery resistance index) at 32 weeks at multivariable analysis: (1) right ventricular function (tricuspid annular plane systolic excursion) (P=0.002), (2) high N-terminal pro-B-type natriuretic peptide (P=0.085), (3) systemic (P=0.001), and (4) pulmonary (P=0.045) atrioventricular valve regurgitation. Women with CHD had more obstetric (58.9% versus 32.9%, P<0.0001) and offspring events (35.4% versus 18.6%, P=0.008) than healthy women. Impaired UDF was associated with adverse obstetric and offspring outcome. CONCLUSIONS: UDF parameters are abnormal in pregnant women with CHD. Cardiovascular function is associated with an abnormal pattern of UDF. Compromised UDF may be a key factor in the high incidence of offspring and obstetric complications in this population.
BACKGROUND: Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS: We performed a prospective multicenter cohort study of pregnant women with CHD and healthy pregnant women. We compared clinical, laboratory, echocardiographic, and uteroplacental Doppler flow (UDF) parameters at 20 and 32 weeks gestation, and pregnancy outcome. We related cardiovascular parameters to UDF parameters and pregnancy outcome in women with CHD. We included 209 women with CHD and 70 healthy women. Cardiovascular parameters (N-terminal pro-B-type natriuretic peptide, left and right ventricular function) differed between both groups. UDF parameters were impaired in CHD women (umbilical artery pulsatility and resistance index at 32 weeks in CHD versus healthy women, P=0.0085 and P=0.017). The following cardiovascular parameters prepregnancy and at 20 weeks gestation were associated with UDF (umbilical artery resistance index) at 32 weeks at multivariable analysis: (1) right ventricular function (tricuspid annular plane systolic excursion) (P=0.002), (2) high N-terminal pro-B-type natriuretic peptide (P=0.085), (3) systemic (P=0.001), and (4) pulmonary (P=0.045) atrioventricular valve regurgitation. Women with CHD had more obstetric (58.9% versus 32.9%, P<0.0001) and offspring events (35.4% versus 18.6%, P=0.008) than healthy women. Impaired UDF was associated with adverse obstetric and offspring outcome. CONCLUSIONS: UDF parameters are abnormal in pregnant women with CHD. Cardiovascular function is associated with an abnormal pattern of UDF. Compromised UDF may be a key factor in the high incidence of offspring and obstetric complications in this population.
Authors: Anum S Minhas; Faisal Rahman; Nicole Gavin; Ari Cedars; Arthur Jason Vaught; Sammy Zakaria; Jon Resar; Stefano Schena; Steven Schulman; Di Zhao; Allison G Hays; Erin D Michos Journal: Am J Cardiol Date: 2021-08-24 Impact factor: 2.778
Authors: Nils Thomas Songstad; Maria C Serrano; Vasilis Sitras; David Johansen; Davis Johansen; Kirsti Ytrehus; Ganesh Acharya Journal: PLoS One Date: 2014-07-09 Impact factor: 3.240