Current treatment and future prospects for peripheral T-cell lymphoma.

The management of peripheral T-cell lymphoma (PTCL) remains a big challenge. PTCL exists as a collection of subentities, which are all rare. Each subtype described has its own unique pathogenesis, etiological associations and presentation. In general, PTCL is a relatively resistant disorder that exhibits extranodal features, B symptoms and paraneoplastic phenomena. This condition is prone to relapse, with a disappointing overall survival at 5 years of approximately 30%. This review will discuss the differences in the tumor biology of PTCL subentities, their associated targeted therapies, options for first-line treatment and the role of stem cell transplantation in first-line and relapsed settings. The authors then discuss new agents being used in early phase trials in relapsed/refractory disease and discuss the urgent need for collaborative randomized controlled trials in this resistant and biologically aggressive disease group. Copyright 2013 Prous Science, S.A.U. or its licensors. All rights reserved.