Immunological aspects of virology. WHO Working Group.

This article summarizes the conclusions of a WHO Working Group concerning progress towards an improved understanding of the mechanisms of natural and vaccine-induced immunity to viral infection in man. Particular attention is given to the role of humoral immunity, non-specific cellular and virus-specific T-cell responses, interferons and lymphokines in the immune response to virus infection. Detailed knowledge of the immune responses relevant to protection by vaccines is important for a rational approach to vaccine design. Recommendations are made for future collaborative research in immunovirology with due consideration given to the needs of the recently established WHO Vaccine Development Programme.