PURPOSE: To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3). METHOD: Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group. RESULTS: All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (p < 0.001) suggesting a role for PAI-1 mutation in RM and IF. CONCLUSIONS: The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.
PURPOSE: To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3). METHOD: Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group. RESULTS: All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (p < 0.001) suggesting a role for PAI-1 mutation in RM and IF. CONCLUSIONS: The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.
Authors: M Margaglione; E Grandone; G Vecchione; G Cappucci; N Giuliani; D Colaizzo; E Celentano; S Panico; G Di Minno Journal: Arterioscler Thromb Vasc Biol Date: 1997-10 Impact factor: 8.311
Authors: A B Coumans; P C Huijgens; C Jakobs; R Schats; J I de Vries; M G van Pampus; G A Dekker Journal: Hum Reprod Date: 1999-01 Impact factor: 6.918
Authors: José Bellver; Sergio R Soares; Claudio Alvarez; Elkin Muñoz; Alberto Ramírez; Carmen Rubio; Vicente Serra; José Remohí; Antonio Pellicer Journal: Hum Reprod Date: 2007-12-10 Impact factor: 6.918
Authors: M J Kupferminc; A Eldor; N Steinman; A Many; A Bar-Am; A Jaffa; G Fait; J B Lessing Journal: N Engl J Med Date: 1999-01-07 Impact factor: 91.245
Authors: Yao Ye; Aurelia Vattai; Xi Zhang; Junyan Zhu; Christian J Thaler; Sven Mahner; Udo Jeschke; Viktoria von Schönfeldt Journal: Int J Mol Sci Date: 2017-07-29 Impact factor: 5.923