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Literature DB >> 24189526

Metformin: do we finally have an anti-aging drug?

Abstract

Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases lifespan in nematodes, fruit flies, and mice. Life-prolonging effects of caloric restriction are in part due to reduction in IGF-1, insulin, and glucose levels. Antidiabetic biguanides such as metformin, which reduce hyperglycemia and hyperinsulinemia by decreasing insulin resistance, extend lifespan, and inhibit carcinogenesis in rodents. Will antidiabetic biguanides increase lifespan in humans?

Entities: Chemical Disease Gene Species

Keywords: aging; cancer; diabetes; geroconversion; gerosuppression

Mesh：

Substances：

Year: 2013 PMID： 24189526 PMCID： PMC3906334 DOI： 10.4161/cc.26928

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

62 in total

1. Metformin and fatty acids.

Authors: S Muntoni
Journal: Diabetes Care Date: 1999-01 Impact factor: 19.112

2. Metformin therapy in a transgenic mouse model of Huntington's disease.

Authors: Thong C Ma; Jessica L Buescher; Benjamin Oatis; Jason A Funk; Andrew J Nash; Raeann L Carrier; Kari R Hoyt
Journal: Neurosci Lett Date: 2006-11-15 Impact factor: 3.046

Review 3. Calorie restriction mimetics: an emerging research field.

Authors: Donald K Ingram; Min Zhu; Jacek Mamczarz; Sige Zou; Mark A Lane; George S Roth; Rafael deCabo
Journal: Aging Cell Date: 2006-04 Impact factor: 9.304

4. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Authors: Reuben J Shaw; Katja A Lamia; Debbie Vasquez; Seung-Hoi Koo; Nabeel Bardeesy; Ronald A Depinho; Marc Montminy; Lewis C Cantley
Journal: Science Date: 2005-11-24 Impact factor: 47.728

5. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

Authors: Vladimir N Anisimov; Lev M Berstein; Peter A Egormin; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Irina G Kovalenko; Tatiana E Poroshina; Anna V Semenchenko; Mauro Provinciali; Francesca Re; Claudio Franceschi
Journal: Exp Gerontol Date: 2005 Aug-Sep Impact factor: 4.032

6. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.

Authors: Chong Chen; Yu Liu; Yang Liu; Pan Zheng
Journal: Sci Signal Date: 2009-11-24 Impact factor: 8.192

7. Growth stimulation leads to cellular senescence when the cell cycle is blocked.

Authors: Zoya N Demidenko; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2008-11-12 Impact factor: 4.534

Review 8. Carcinogenesis and aging 20 years after: escaping horizon.

Authors: Vladimir N Anisimov
Journal: Mech Ageing Dev Date: 2008-02-15 Impact factor: 5.432

9. Pioglitazone: an anti-diabetic compound with anti-aging properties.

Authors: Mahtab Jafari; Behnood Khodayari; Jeffrey Felgner; Irvin I Bussel; Michael R Rose; Laurence D Mueller
Journal: Biogerontology Date: 2007-07-13 Impact factor: 4.277

10. Metformin slows down aging and extends life span of female SHR mice.

Authors: Vladimir N Anisimov; Lev M Berstein; Peter A Egormin; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Margarita L Tyndyk; Maria V Yurova; Irina G Kovalenko; Tatiana E Poroshina; Anna V Semenchenko
Journal: Cell Cycle Date: 2008-09-11 Impact factor: 4.534

48 in total

1. Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

Authors: Harvir Hans; Asad Lone; Vadim Aksenov; C David Rollo
Journal: Age (Dordr) Date: 2015-04-02

Review 2. Nutritional strategies to optimise cognitive function in the aging brain.

Authors: Devin Wahl; Victoria C Cogger; Samantha M Solon-Biet; Rosilene V R Waern; Rahul Gokarn; Tamara Pulpitel; Rafael de Cabo; Mark P Mattson; David Raubenheimer; Stephen J Simpson; David G Le Couteur
Journal: Ageing Res Rev Date: 2016-06-26 Impact factor: 10.895

3. 60 years of metformin use: a glance at the past and a look to the future.

Authors: Sally M Marshall
Journal: Diabetologia Date: 2017-09 Impact factor: 10.122

Review 4. Immunosenescence: a key player in cancer development.

Authors: Jingyao Lian; Ying Yue; Weina Yu; Yi Zhang
Journal: J Hematol Oncol Date: 2020-11-10 Impact factor: 17.388

Review 5. In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.

Authors: Zbigniew Darzynkiewicz; Hong Zhao; H Dorota Halicka; Jiangwei Li; Yong-Syu Lee; Tze-Chen Hsieh; Joseph M Wu
Journal: Cytometry A Date: 2014-02-22 Impact factor: 4.355

6. Metformin targets histone acetylation in cancer-prone epithelial cells.

Authors: Elisabet Cuyàs; Salvador Fernández-Arroyo; Jorge Joven; Javier A Menendez
Journal: Cell Cycle Date: 2016-10-28 Impact factor: 4.534

7. Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.

Authors: Irina G Popovich; Vladimir N Anisimov; Mark A Zabezhinski; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Mikhail V Blagosklonny
Journal: Cancer Biol Ther Date: 2014-02-20 Impact factor: 4.742

8. Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin.

Authors: Vladimir N Anisimov; Irina G Popovich; Mark A Zabezhinski; Peter A Egormin; Maria N Yurova; Anna V Semenchenko; Margarita L Tyndyk; Andrey V Panchenko; Alexandr P Trashkov; Andrey G Vasiliev; Nikolai V Khaitsev
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

9. Comparison of rapamycin schedules in mice on high-fat diet.

Authors: Olga V Leontieva; Geraldine M Paszkiewicz; Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2014 Impact factor: 4.534

Review 10. Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases.

Authors: Jun Ren; Yingmei Zhang
Journal: Trends Pharmacol Sci Date: 2018-10-26 Impact factor: 14.819