| Literature DB >> 24189284 |
Sunil Mahurkar1, Vijayaprakash Suppiah, Catherine O'Doherty.
Abstract
Multiple sclerosis (MS) is one of the most common inflammatory and degenerative autoimmune diseases of the central nervous system with considerable heterogeneity in all aspects, including response to therapy. A number of disease modifying drugs, including traditional first line agents such as, interferon-beta (IFN-β) and glatiramer acetate (GA) are available for disease management. However, a considerable number of patients fail to achieve adequate response at therapeutic doses of IFN-β or GA. This variability in response to treatment has prompted the search for prognostic markers in order to personalize and optimize therapy so as to treat MS more efficiently. This review will summarize the existing literature examining the pharmacogenomics of IFN-β and GA response in MS patients.Entities:
Keywords: APC; BBB; BDNF; CNS; DMD; EAE; EDSS; GA; GWAS; Genetics; Glatiramer acetate; HCV; HHV; HLA; IFN; IFN-β; ISG; ISRE; Interferon beta; MHC; MRI; MS; Multiple sclerosis; NAb; NR; NT; Pharmacogenomics; R; RRMS; Response; SNP; antigen-presenting cell; blood–brain barrier; brain-derived neurotrophic factor; central nervous system; disease modifying drug; expanded disability status scale; experimental autoimmune encephalomyelitis; genome wide association study; glatiramer acetate; hepatitis C virus; human herpes virus; human leukocyte antigen; interferon; interferon-beta; interferon-stimulated gene; interferon-stimulated response element; magnetic resonance imaging; major histocompatibility complex; multiple sclerosis; neurotrophin; neutralizing antibody; non-responder; relapsing-remitting multiple sclerosis; responder; single nucleotide polymorphism
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Year: 2013 PMID： 24189284 DOI： 10.1016/j.autrev.2013.10.012
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754