| Literature DB >> 24188034 |
Juliana C Gomes1, Jordi Sirvent, Albert Moyano, Manoel T Rodrigues, Fernando Coelho.
Abstract
The readily available bicyclic imidazolyl alcohol 1 is a unique catalyst for the aqueous Morita-Baylis-Hillman (MBH) reaction between unprotected isatins and cyclic enones that gives access to a variety of potentially very useful 3-substituted 3-hydroxy-2-oxindoles in an operationally simple, efficient, and environmentally friendly way. The hydroxyl group of the catalyst is believed to stabilize the betaine intermediate formed in the first step of the MBH reaction.Entities:
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Year: 2013 PMID： 24188034 DOI： 10.1021/ol4029034
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005