Literature DB >> 24187571

Imaging vertebrate digestive function and lipid metabolism in vivo.

Jessica P Otis1, Steven A Farber.   

Abstract

Challenges in imaging lipid-processing events in live, intact vertebrate models have historically led to reliance on cultured cell studies, thus hampering our understanding of lipid metabolism and gastrointestinal physiology. Fluorescently-labeled molecules, such as BODIPY-labeled lipids, can reveal lipid-processing events in live zebrafish (Danio rerio) and has expanded our understanding of digestive physiology. This review will cover recent advances from the past two to three years in the use of fluorescence-based imaging techniques in live zebrafish to characterize gastrointestinal physiology in health and disease and to conduct small molecule screens to discover therapeutic compounds.

Entities:  

Year:  2013        PMID： 24187571      PMCID： PMC3811959          DOI： 10.1016/j.ddmod.2012.02.008

Source DB:  PubMed          Journal:  Drug Discov Today Dis Models        ISSN： 1740-6757


  40 in total

1.  Genetic analysis of digestive physiology using fluorescent phospholipid reporters.

Authors:  S A Farber; M Pack; S Y Ho; I D Johnson; D S Wagner; R Dosch; M C Mullins; H S Hendrickson; E K Hendrickson; M E Halpern
Journal:  Science       Date:  2001-05-18       Impact factor: 47.728

2.  A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol.

Authors:  Sandhya Sankaranarayanan; Ginny Kellner-Weibel; Margarita de la Llera-Moya; Michael C Phillips; Bela F Asztalos; Robert Bittman; George H Rothblat
Journal:  J Lipid Res       Date:  2011-09-27       Impact factor: 5.922

3.  Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.

Authors:  Shaobing O Zhang; Andrew C Box; Ningyi Xu; Johan Le Men; Jingyi Yu; Fengli Guo; Rhonda Trimble; Ho Yi Mak
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-22       Impact factor: 11.205

4.  Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6.

Authors:  Randolph P Matthews; Nicolas Plumb-Rudewiez; Kristin Lorent; Paul Gissen; Colin A Johnson; Frederic Lemaigre; Michael Pack
Journal:  Development       Date:  2005-12       Impact factor: 6.868

Review 5.  Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol.

Authors:  Jennifer L Anderson; Juliana D Carten; Steven A Farber
Journal:  Methods Cell Biol       Date:  2011       Impact factor: 1.441

6.  Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation.

Authors:  Longhou Fang; Richard Harkewicz; Karsten Hartvigsen; Philipp Wiesner; Soo-Ho Choi; Felicidad Almazan; Jennifer Pattison; Elena Deer; Tiffany Sayaphupha; Edward A Dennis; Joseph L Witztum; Sotirios Tsimikas; Yury I Miller
Journal:  J Biol Chem       Date:  2010-08-14       Impact factor: 5.157

7.  The microRNA-30 family is required for vertebrate hepatobiliary development.

Authors:  Nicholas J Hand; Zankhana R Master; Steven F Eauclaire; Daniel E Weinblatt; Randolph P Matthews; Joshua R Friedman
Journal:  Gastroenterology       Date:  2008-12-09       Impact factor: 22.682

Review 8.  The behaviour and ecology of the zebrafish, Danio rerio.

Authors:  Rowena Spence; Gabriele Gerlach; Christian Lawrence; Carl Smith
Journal:  Biol Rev Camb Philos Soc       Date:  2007-12-17

Review 9.  Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight.

Authors:  Luca Parente; Mauro Perretti
Journal:  Biochem Pharmacol       Date:  2003-01-15       Impact factor: 5.858

10.  Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome.

Authors:  Michael A Pickart; Eric W Klee; Aubrey L Nielsen; Sridhar Sivasubbu; Eric M Mendenhall; Brent R Bill; Eleanor Chen; Craig E Eckfeldt; Michelle Knowlton; Mara E Robu; Jon D Larson; Yun Deng; Lisa A Schimmenti; Lynda B M Ellis; Catherine M Verfaillie; Matthias Hammerschmidt; Steven A Farber; Stephen C Ekker
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240
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  10 in total

1.  An HPLC-CAD/fluorescence lipidomics platform using fluorescent fatty acids as metabolic tracers.

Authors:  Vanessa H Quinlivan; Meredith H Wilson; Josef Ruzicka; Steven A Farber
Journal:  J Lipid Res       Date:  2017-03-09       Impact factor: 5.922

2.  High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake.

Authors:  Jessica P Otis; Steven A Farber
Journal:  J Vis Exp       Date:  2016-10-27       Impact factor: 1.355

3.  Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function.

Authors:  Timothy Kassis; Alison B Kohan; Michael J Weiler; Matthew E Nipper; Rachel Cornelius; Patrick Tso; J Brandon Dixon
Journal:  J Biomed Opt       Date:  2012-08       Impact factor: 3.170

4.  Aspect ratio plays a role in the hazard potential of CeO2 nanoparticles in mouse lung and zebrafish gastrointestinal tract.

Authors:  Sijie Lin; Xiang Wang; Zhaoxia Ji; Chong Hyun Chang; Yuan Dong; Huan Meng; Yu-Pei Liao; Meiying Wang; Tze-Bin Song; Sirus Kohan; Tian Xia; Jeffrey I Zink; Shuo Lin; André E Nel
Journal:  ACS Nano       Date:  2014-04-16       Impact factor: 15.881

5.  Using fluorescent lipids in live zebrafish larvae: From imaging whole animal physiology to subcellular lipid trafficking.

Authors:  J L Anderson; J D Carten; S A Farber
Journal:  Methods Cell Biol       Date:  2016-05-09       Impact factor: 1.441

6.  Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake.

Authors:  Jessica P Otis; Erin M Zeituni; James H Thierer; Jennifer L Anderson; Alexandria C Brown; Erica D Boehm; Derek M Cerchione; Alexis M Ceasrine; Inbal Avraham-Davidi; Hanoch Tempelhof; Karina Yaniv; Steven A Farber
Journal:  Dis Model Mech       Date:  2015-01-29       Impact factor: 5.758

7.  Probiotic treatment reduces appetite and glucose level in the zebrafish model.

Authors:  Silvia Falcinelli; Ana Rodiles; Suraj Unniappan; Simona Picchietti; Giorgia Gioacchini; Daniel Lee Merrifield; Oliana Carnevali
Journal:  Sci Rep       Date:  2016-01-05       Impact factor: 4.379

Review 8.  Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish.

Authors:  Vanessa H Quinlivan; Steven A Farber
Journal:  Front Endocrinol (Lausanne)       Date:  2017-11-20       Impact factor: 5.555

9.  A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export.

Authors:  Ismael Gomez-Martinez; R Jarrett Bliton; Keith A Breau; Michael J Czerwinski; Ian A Williamson; Jia Wen; John F Rawls; Scott T Magness
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2022-04-28

10.  Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism.

Authors:  Rosa L Miyares; Vitor B de Rezende; Steven A Farber
Journal:  Dis Model Mech       Date:  2014-05-08       Impact factor: 5.758
  10 in total

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