Literature DB >> 24186381

Corticosteroid treatment normalizes QTc prolongation and improves heart block in an elderly patient with anti-Ro-positive systemic lupus erythematosus.

Maksat Saribayev1, Fatih Tufan, Fahrettin Oz, Burak Erer, Tahsin Ozpolat, Gulistan Bahat Ozturk, Sibel Akin, Bulent Saka, Nilgun Erten, Cemil Tascioglu, Akif Karan.   

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic disease which potentially involves various organs including the skin, joints, kidneys, liver, hematopoetic system, and serous membranes. It is rarely seen in elderly males. The most common cardiovascular involvement type is pericarditis. Anti-Ro antibodies may be associated with neonatal lupus which causes heart blocks. Recent literature indicates that anti-Ro antibodies may be associated with various rhythm and conduction disturbances in the adulthood. The most common finding associated with anti-Ro antibodies is prolonged corrected QT (QTc) interval. Herein, we present an elderly male patient with anti-Ro-positive SLE associated with prolonged QTc interval and AV blocks that significantly improved after corticosteroid treatment.

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Year:  2013        PMID: 24186381     DOI: 10.1007/s40520-013-0168-9

Source DB:  PubMed          Journal:  Aging Clin Exp Res        ISSN: 1594-0667            Impact factor:   3.636


  5 in total

1.  Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases.

Authors:  Ayse Nur Tufan; Saim Sag; Mustafa Ferhat Oksuz; Selime Ermurat; Belkis Nihan Coskun; Mustafa Gullulu; Ferah Budak; Ibrahim Baran; Yavuz Pehlivan; Ediz Dalkilic
Journal:  Rheumatol Int       Date:  2016-05-18       Impact factor: 2.631

Review 2.  Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies.

Authors:  Pietro Enea Lazzerini; Pier Leopoldo Capecchi; Nabil El-Sherif; Franco Laghi-Pasini; Mohamed Boutjdir
Journal:  J Am Heart Assoc       Date:  2018-11-20       Impact factor: 5.501

Review 3.  Long QT Syndrome: An Emerging Role for Inflammation and Immunity.

Authors:  Pietro Enea Lazzerini; Pier Leopoldo Capecchi; Franco Laghi-Pasini
Journal:  Front Cardiovasc Med       Date:  2015-05-27

Review 4.  The Role of Autoantibodies in Arrhythmogenesis.

Authors:  Jin Li
Journal:  Curr Cardiol Rep       Date:  2020-11-25       Impact factor: 2.931

5.  A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity.

Authors:  Jörg Täubel; Alessandro Mazzetti; Georg Ferber; William Burch; Sara Fernandes; Avani Patel; Christopher S Spencer; Anne Freier; Claus Graff; Jørgen K Kanters; John Camm
Journal:  Clin Pharmacol Drug Dev       Date:  2021-05-03
  5 in total

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