Literature DB >> 2418540

In vitro effect of aflatoxin B1 on rat liver macrophages (Kuffer cells).

N K Mohapatra, J F Roberts.   

Abstract

The effect of aflatoxin B1 on the uptake and incorporation of [3H]leucine and [3H]uridine and on phagocytosis of latex particles was studied using cultures of rat liver macrophages (Kuffer cells). Aflatoxin B1 inhibited the incorporation of both isotopes, but inhibition of uridine incorporation was greater than that of leucine, suggesting that RNA synthesis was a major site of inhibition. Aflatoxin B1 also inhibited phagocytosis of latex particles in a time- and dose-dependent manner.

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Year:  1985        PMID： 2418540     DOI： 10.1016/0378-4274(85)90039-6

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  3 in total

1.  Aflatoxin B1 Induces Reactive Oxygen Species-Mediated Autophagy and Extracellular Trap Formation in Macrophages.

Authors:  Yanan An; Xiaochen Shi; Xudong Tang; Yang Wang; Fengge Shen; Qiaoli Zhang; Chao Wang; Mingguo Jiang; Mingyuan Liu; Lu Yu
Journal:  Front Cell Infect Microbiol       Date:  2017-02-23       Impact factor: 5.293

Review 2.  Contamination of Aflatoxins Induces Severe Hepatotoxicity Through Multiple Mechanisms.

Authors:  Zhenglai Hua; Rui Liu; Youwen Chen; Guangzhi Liu; Chenxi Li; Yurong Song; Zhiwen Cao; Wen Li; Weifeng Li; Cheng Lu; Yuanyan Liu
Journal:  Front Pharmacol       Date:  2021-01-11       Impact factor: 5.810

3.  Production of a monoclonal antibody against aflatoxin M1 and its application for detection of aflatoxin M1 in fortified milk.

Authors:  Umarphorn Chadseesuwan; Apinya Sangdokmai; Umaporn Pimpitak; Songchan Puthong; Tanapat Palaga; Kittinan Komolpis
Journal:  J Food Drug Anal       Date:  2016-04-28       Impact factor: 6.157
  3 in total

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