D Hayashi1, D T Felson2, J Niu2, D J Hunter3, F W Roemer4, P Aliabadi5, A Guermazi6. 1. Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Radiology, Bridgeport Hospital, Bridgeport, CT 06610, USA. Electronic address: dhayashi@bu.edu. 2. Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA. 3. Kolling Institute, University of Sydney, Sydney, NSW, Australia. 4. Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Radiology, University of Erlangen, Erlangen, Germany. 5. Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA. 6. Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA.
Abstract
OBJECTIVE: To determine which subregions of the knee joint have a high prevalence of pre-radiographic osteoarthritic changes, i.e., cartilage damage and osteophytes that can only be detected by magnetic resonance imaging (MRI), in radiographically normal knees. METHODS: Institutional Review Board approval and written informed consent from all participants was obtained. Data was collected from a community cohort in Framingham, MA, involving people aged 50-79. Participants underwent weight-bearing posteroanterior and lateral knee radiography with the fixed-flexion protocol, and 1.5 T MRI. Knees without radiographic osteoarthritis (Kellgren Lawrence grade 0 for the tibiofemoral joint and absence of any osteophytes or joint space narrowing in the patellofemoral joint) were included. The knee joint was divided into 14 subregions for cartilage and 16 subregions for osteophytes, and prevalence and severity of cartilage damage (grade 0-6) and osteophytes (grade 0-7) were semiquantitatively assessed using the Whole Organ Magnetic Resonance Imaging Score (WORMS). RESULTS: The mean age of 696 participants was 62.3 ± 8.4 years, and the mean body mass index was 27.9 ± 5.1 kg/m2. Women comprised 55.2% of the study sample (384/696). Prevalence of cartilage damage (grade ≥2) was 47.7% (332/696) in the medial patellar and 29.9% (208/696) in patellar lateral (PL) subregions, and 24.0% (167/696) in femoral medial anterior (FMA) and 26.5% (184/696) in femoral medial central (FMC) subregions. Prevalence of osteophytes (grade ≥2) was highest at 60.8% (423/696) in the medial femoral posterior subregion, followed by 34.0% (237/696) in PL and 24.6% (171/696) in patellar medial (PM) subregions. For all other subregions, prevalence of these lesions was lower than the aforementioned percentages. CONCLUSION: MRI-detected cartilage damage and osteophytes are highly prevalent in the medial patellofemoral and medial posterior tibiofemoral joints in radiographically normal knees in persons aged 50-79.
OBJECTIVE: To determine which subregions of the knee joint have a high prevalence of pre-radiographic osteoarthritic changes, i.e., cartilage damage and osteophytes that can only be detected by magnetic resonance imaging (MRI), in radiographically normal knees. METHODS: Institutional Review Board approval and written informed consent from all participants was obtained. Data was collected from a community cohort in Framingham, MA, involving people aged 50-79. Participants underwent weight-bearing posteroanterior and lateral knee radiography with the fixed-flexion protocol, and 1.5 T MRI. Knees without radiographic osteoarthritis (Kellgren Lawrence grade 0 for the tibiofemoral joint and absence of any osteophytes or joint space narrowing in the patellofemoral joint) were included. The knee joint was divided into 14 subregions for cartilage and 16 subregions for osteophytes, and prevalence and severity of cartilage damage (grade 0-6) and osteophytes (grade 0-7) were semiquantitatively assessed using the Whole Organ Magnetic Resonance Imaging Score (WORMS). RESULTS: The mean age of 696 participants was 62.3 ± 8.4 years, and the mean body mass index was 27.9 ± 5.1 kg/m2. Women comprised 55.2% of the study sample (384/696). Prevalence of cartilage damage (grade ≥2) was 47.7% (332/696) in the medial patellar and 29.9% (208/696) in patellar lateral (PL) subregions, and 24.0% (167/696) in femoral medial anterior (FMA) and 26.5% (184/696) in femoral medial central (FMC) subregions. Prevalence of osteophytes (grade ≥2) was highest at 60.8% (423/696) in the medial femoral posterior subregion, followed by 34.0% (237/696) in PL and 24.6% (171/696) in patellar medial (PM) subregions. For all other subregions, prevalence of these lesions was lower than the aforementioned percentages. CONCLUSION: MRI-detected cartilage damage and osteophytes are highly prevalent in the medial patellofemoral and medial posterior tibiofemoral joints in radiographically normal knees in persons aged 50-79.
Authors: T M Link; C A Sell; J N Masi; C Phan; D Newitt; Y Lu; L Steinbach; S Majumdar Journal: Osteoarthritis Cartilage Date: 2005-09-26 Impact factor: 6.576
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: Ali Guermazi; Daichi Hayashi; Felix Eckstein; David J Hunter; Jeff Duryea; Frank W Roemer Journal: Rheum Dis Clin North Am Date: 2013-02 Impact factor: 2.670
Authors: A Guermazi; D Hayashi; F Roemer; D T Felson; K Wang; J Lynch; S Amin; J Torner; C E Lewis; M C Nevitt Journal: Osteoarthritis Cartilage Date: 2015-04-28 Impact factor: 6.576
Authors: Frank W Roemer; C Kent Kwoh; Michael J Hannon; David J Hunter; Felix Eckstein; Tomoko Fujii; Robert M Boudreau; Ali Guermazi Journal: Arthritis Rheumatol Date: 2015-05 Impact factor: 10.995
Authors: Ali Guermazi; Daichi Hayashi; Frank W Roemer; Jingbo Niu; Emily K Quinn; Michel D Crema; Michael C Nevitt; James Torner; Cora E Lewis; David T Felson Journal: Arthritis Rheumatol Date: 2017-03 Impact factor: 10.995