Raffaele Serra1, Gianluca Buffone2, Giuseppe Costanzo3, Rossella Montemurro2, Edoardo Scarcello4, Domenico Marco Stillitano2, Rocco Damiano3, Stefano de Franciscis5. 1. Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy; Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy. Electronic address: rserra@unicz.it. 2. Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy. 3. Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy. 4. Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy. 5. Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy; Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Abstract
BACKGROUND: Varicocele, inguinal hernia, and clinical manifestations related to chronic venous disorders are often associated, and collagen metabolism together with metalloproteinases (MMPs) alterations may be implicated. The aim of this study was to analyze the relationship between these factors. METHODS: We evaluated tissue and plasma samples from patients with varicocele, inguinal hernia, and great saphenous vein reflux, who underwent surgical treatment for their conditions. We then analyzed and correlated these findings with MMP levels. RESULTS: Significantly higher levels of MMP-1, -2, -12, and -13 were found in patients with inguinal hernia. MMP-9 levels were higher in patients with at least two of the conditions indicated. CONCLUSION: MMP-9 seems to be the common thread in various clinical conditions and is related to a more general and progressive disorder of collagen metabolism.
BACKGROUND: Varicocele, inguinal hernia, and clinical manifestations related to chronic venous disorders are often associated, and collagen metabolism together with metalloproteinases (MMPs) alterations may be implicated. The aim of this study was to analyze the relationship between these factors. METHODS: We evaluated tissue and plasma samples from patients with varicocele, inguinal hernia, and great saphenous vein reflux, who underwent surgical treatment for their conditions. We then analyzed and correlated these findings with MMP levels. RESULTS: Significantly higher levels of MMP-1, -2, -12, and -13 were found in patients with inguinal hernia. MMP-9 levels were higher in patients with at least two of the conditions indicated. CONCLUSION:MMP-9 seems to be the common thread in various clinical conditions and is related to a more general and progressive disorder of collagen metabolism.
Authors: Raffaele Serra; Raffaele Grande; Lucia Butrico; Gianluca Buffone; Francesco G Caliò; Aida Squillace; Barbara A Rizzo; Mafalda Massara; Francesco Spinelli; Alessia G Ferrarese; Giovanni de Caridi; Luca Gallelli; Stefano de Franciscis Journal: Int Wound J Date: 2014-02-25 Impact factor: 3.315
Authors: Nicholas K Larsen; Matthew J Reilly; Finosh G Thankam; Robert J Fitzgibbons; Devendra K Agrawal Journal: Expert Rev Clin Immunol Date: 2019-04-25 Impact factor: 4.473
Authors: Stefano de Franciscis; Giovanni De Caridi; Mafalda Massara; Francesco Spinelli; Luca Gallelli; Gianluca Buffone; Francesco G Caliò; Lucia Butrico; Raffaele Grande; Raffaele Serra Journal: Int Wound J Date: 2014-12-03 Impact factor: 3.315
Authors: Raffaele Serra; Bruno Amato; Lucia Butrico; Andrea Barbetta; Giovanni De Caridi; Mafalda Massara; Francesco G Caliò; Chiara Longo; Gianfranco Dardano; Marco Cannistrà; Gianluca Buffone; Stefano de Franciscis Journal: Int Wound J Date: 2016-05-15 Impact factor: 3.315
Authors: Giovanni De Caridi; Mafalda Massara; Francesco Stilo; Francesco Spinelli; Raffaele Grande; Lucia Butrico; Stefano de Franciscis; Raffaele Serra Journal: Int Wound J Date: 2014-08-05 Impact factor: 3.315
Authors: Raffaele Serra; Luca Gallelli; Lucia Butrico; Gianluca Buffone; Francesco G Caliò; Giovanni De Caridi; Mafalda Massara; Andrea Barbetta; Bruno Amato; Miriam Labonia; Selena Mimmi; Enrico Iaccino; Stefano de Franciscis Journal: Int Wound J Date: 2016-03-15 Impact factor: 3.315
Authors: Stefano de Franciscis; Salvatore Fregola; Alessandro Gallo; Giuseppe Argirò; Andrea Barbetta; Gianluca Buffone; Francesco G Caliò; Giovanni De Caridi; Bruno Amato; Raffaele Serra Journal: Int Wound J Date: 2015-11-06 Impact factor: 3.315