Chao-Chun Yang1, Fu-Nien Hsieh2, Li-Yu Lin2, Chao-Kai Hsu1, Hamm-Ming Sheu3, WenChieh Chen4. 1. Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Research Center of Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan. 2. Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 3. Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: hmsheu@mail.ncku.edu.tw. 4. Department of Dermatology and Allergy, Technische Universität München, Germany. Electronic address: wenchieh.chen@lrz.tum.de.
Abstract
BACKGROUND: Obesity is a risk factor for multiple health problems, but its association with androgenetic alopecia (AGA) remains controversial. OBJECTIVE: We sought to determine the association between body mass index (BMI) and alopecia severity in men with AGA and early-onset AGA. METHODS: A cross-sectional study was conducted. The medical charts and photographs of men with a clinical diagnosis of AGA were reviewed. RESULTS: In all, 189 men were enrolled with a mean age of 30.8 years. In male-pattern AGA (n = 142), men with severe alopecia (grade V-VII) had higher BMI than those with mild to moderate alopecia (grade I-IV) (25.1 vs 22.8 kg/m(2), P = .01). After multivariate adjustments, the risk for severe alopecia was higher in the overweight or obese (BMI ≥24 kg/m(2)) subjects with male-pattern AGA (odds ratio 3.52, P < .01). In early-onset male-pattern AGA (n = 46), the risk for having severe alopecia was also higher in the overweight or obese subjects (odds ratio 4.97, P = .03). LIMITATIONS: Parameters used to evaluate obesity were limited because of the retrospective nature of the study. CONCLUSIONS: Higher BMI was significantly associated with greater severity of hair loss in men with male-pattern AGA, especially in those with early-onset AGA.
BACKGROUND:Obesity is a risk factor for multiple health problems, but its association with androgenetic alopecia (AGA) remains controversial. OBJECTIVE: We sought to determine the association between body mass index (BMI) and alopecia severity in men with AGA and early-onset AGA. METHODS: A cross-sectional study was conducted. The medical charts and photographs of men with a clinical diagnosis of AGA were reviewed. RESULTS: In all, 189 men were enrolled with a mean age of 30.8 years. In male-pattern AGA (n = 142), men with severe alopecia (grade V-VII) had higher BMI than those with mild to moderate alopecia (grade I-IV) (25.1 vs 22.8 kg/m(2), P = .01). After multivariate adjustments, the risk for severe alopecia was higher in the overweight or obese (BMI ≥24 kg/m(2)) subjects with male-pattern AGA (odds ratio 3.52, P < .01). In early-onset male-pattern AGA (n = 46), the risk for having severe alopecia was also higher in the overweight or obese subjects (odds ratio 4.97, P = .03). LIMITATIONS: Parameters used to evaluate obesity were limited because of the retrospective nature of the study. CONCLUSIONS: Higher BMI was significantly associated with greater severity of hair loss in men with male-pattern AGA, especially in those with early-onset AGA.
Authors: Klaudia Dopytalska; Agnieszka Baranowska-Bik; Marek Roszkiewicz; Wojciech Bik; Irena Walecka Journal: Lipids Health Dis Date: 2020-10-02 Impact factor: 3.876