ETHNOPHARMACOLOGICAL RELEVANCE: Hyptis suaveolens is used by the traditional population in several parts of the world to treat inflammation, gastric ulcer and infection and is used as a crude drug to relieve symptoms related with gastric ulcer or gastritis in northeaster and central region of Brazil. MATERIALS AND METHODS: the standardized ethanolic extract (Hs-EtOHE) and hexanic fraction (Hs-HexF) of Hyptis suaveolens (62,5, 125, 250 and 500 mg/kg) was evaluated in several models of acute gastric ulcers. The participation of NO was evaluated by pretreatment with L-NAME and non-protein sulfyhydryls by NEM in the gastroprotective effect. RESULTS: Hs-EtOHE and Hs-HexF markedly reduced the gastric lesions induced by all ulcerogenic agents (HCl/ethanol, ethanol, NSAIDs and hypothermic restraint-stress). Gastric ulcerations were exacerbated by administration of NEM suggesting that the gastroprotective mechanism of action of Hs-EtOHE and Hs-HexF involves sulfhydryl groups. CONCLUSION: Ours results show that an extract of Hyptis suaveolens, administered orally to rodents, present gastro protective activity in different models of acute of gastric ulcer and give some support to the reported claims on the use of this plant as a gastro protective agent.
ETHNOPHARMACOLOGICAL RELEVANCE: Hyptis suaveolens is used by the traditional population in several parts of the world to treat inflammation, gastric ulcer and infection and is used as a crude drug to relieve symptoms related with gastric ulcer or gastritis in northeaster and central region of Brazil. MATERIALS AND METHODS: the standardized ethanolic extract (Hs-EtOHE) and hexanic fraction (Hs-HexF) of Hyptis suaveolens (62,5, 125, 250 and 500 mg/kg) was evaluated in several models of acute gastric ulcers. The participation of NO was evaluated by pretreatment with L-NAME and non-protein sulfyhydryls by NEM in the gastroprotective effect. RESULTS: Hs-EtOHE and Hs-HexF markedly reduced the gastric lesions induced by all ulcerogenic agents (HCl/ethanol, ethanol, NSAIDs and hypothermic restraint-stress). Gastric ulcerations were exacerbated by administration of NEM suggesting that the gastroprotective mechanism of action of Hs-EtOHE and Hs-HexF involves sulfhydryl groups. CONCLUSION: Ours results show that an extract of Hyptis suaveolens, administered orally to rodents, present gastro protective activity in different models of acute of gastric ulcer and give some support to the reported claims on the use of this plant as a gastro protective agent.
Authors: Leônia Maria Batista; Gedson Rodrigues De Morais Lima; Ana Beatriz Albino De Almeida; Luciana De Pietro Magri; Tamara Regina Calvo; Anderson Luiz Ferreira; Cláudia Helena Pellizzon; Clélia Akiko Hiruma-Lima; Wagner Vilegas; Paulo Takeo Sano; Alba Regina Monteiro Souza Brito Journal: BMC Complement Altern Med Date: 2015-10-29 Impact factor: 3.659
Authors: Heyam Mohamed Ali Sidahmed; Najihah Mohd Hashim; Syam Mohan; Siddig Ibrahim Abdelwahab; Manal Mohamed Elhassan Taha; Firouzeh Dehghan; Maizatulakmal Yahayu; Gwendoline Cheng Lian Ee; Mun Fai Loke; Jamuna Vadivelu Journal: Drug Des Devel Ther Date: 2016-01-13 Impact factor: 4.162
Authors: Adrielle Rodrigues Costa; José Weverton Almeida Bezerra; Rafael Pereira da Cruz; Maria Audilene de Freitas; Viviane Bezerra da Silva; João Cruz Neto; Antonia Thassya Lucas Dos Santos; Maria Flaviana Bezerra Morais Braga; Leomara Andrade da Silva; Maria Ivaneide Rocha; Jean Paul Kamdem; Marcello Iriti; Sara Vitalini; Antonia Eliene Duarte; Luiz Marivando Barros Journal: Antibiotics (Basel) Date: 2020-01-27