Sophie Edouard1, Matthieu Million1, Guilhem Royer1, Roch Giorgi2, Dominique Grisoli3, Didier Raoult4. 1. Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, 13005 Marseille Cedex, France. 2. UMR 912 SESSTIM, Inserm, IRD, Aix-Marseille Université, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex, France. 3. Service de Chirurgie Cardiaque, Hôpital de la Timone, Marseille Cedex, France. 4. Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, 13005 Marseille Cedex, France. Electronic address: didier.raoult@gmail.com.
Abstract
OBJECTIVES: We conducted an observational study to evaluate the impact of our antibioprophylaxis protocols implemented in 2000, on the incidence of Q fever endocarditis diagnosed in our French reference center between 1985 and 2011. METHODS: Endocarditis was diagnosed according to modified Duke Criteria, serological and PCR results. Our prophylaxis recommendations consist of a systematic echocardiography and an antibioprophylaxis in patients with acute Q fever and risk factors for developing endocarditis. RESULTS: Over the last 27 years, we diagnosed 4231 acute Q fever and 818 endocarditis. Despite a significantly increased number of acute Q fever diagnoses and the use of systematic PCR testing of valves allowing serendipitous Q fever endocarditis diagnoses, we observed a decline of Q fever endocarditis. The number of cases has decreased from 316, which represents 18% of newly diagnosed cases of Q fever between 1998 and 2004, to 225, which corresponds to 11% of the cases diagnosed between 2005 and 2011. CONCLUSION: We believe that this decrease was a result of our strategies for prophylaxis. If this assumption is true, we may have prevented more than 150 cases of Q fever endocarditis in France over the past 10 years.
OBJECTIVES: We conducted an observational study to evaluate the impact of our antibioprophylaxis protocols implemented in 2000, on the incidence of Q fever endocarditis diagnosed in our French reference center between 1985 and 2011. METHODS:Endocarditis was diagnosed according to modified Duke Criteria, serological and PCR results. Our prophylaxis recommendations consist of a systematic echocardiography and an antibioprophylaxis in patients with acute Q fever and risk factors for developing endocarditis. RESULTS: Over the last 27 years, we diagnosed 4231 acute Q fever and 818 endocarditis. Despite a significantly increased number of acute Q fever diagnoses and the use of systematic PCR testing of valves allowing serendipitous Q fever endocarditis diagnoses, we observed a decline of Q fever endocarditis. The number of cases has decreased from 316, which represents 18% of newly diagnosed cases of Q fever between 1998 and 2004, to 225, which corresponds to 11% of the cases diagnosed between 2005 and 2011. CONCLUSION: We believe that this decrease was a result of our strategies for prophylaxis. If this assumption is true, we may have prevented more than 150 cases of Q fever endocarditis in France over the past 10 years.
Authors: Cornelia C H Wielders; Joris A F van Loenhout; Gabriëlla Morroy; Ariene Rietveld; Daan W Notermans; Peter C Wever; Nicole H M Renders; Alexander C A P Leenders; Wim van der Hoek; Peter M Schneeberger Journal: PLoS One Date: 2015-07-10 Impact factor: 3.240
Authors: Marit M A de Lange; Laura E V Gijsen; Cornelia C H Wielders; Wim van der Hoek; Arko Scheepmaker; Peter M Schneeberger Journal: Clin Infect Dis Date: 2018-07-18 Impact factor: 9.079
Authors: Loïc Epelboin; Mathieu Nacher; Aba Mahamat; Vincent Pommier de Santi; Alain Berlioz-Arthaud; Carole Eldin; Philippe Abboud; Sébastien Briolant; Emilie Mosnier; Margarete do Socorro Mendonça Gomes; Stephen G Vreden; Magalie Pierre-Demar; Marcus Lacerda; Didier Raoult; Elba Regina Sampaio de Lemos; Félix Djossou Journal: PLoS Negl Trop Dis Date: 2016-05-05