Yoshitaka Okamoto1, Nobuo Ohta2, Mitsuhiro Okano3, Atsushi Kamijo4, Minoru Gotoh5, Motohiko Suzuki6, Sachio Takeno7, Tetsuya Terada8, Toyoyuki Hanazawa9, Shigetoshi Horiguchi10, Kohei Honda11, Shoji Matsune12, Takechiyo Yamada13, Atsushi Yuta14, Takeo Nakayama15, Shigeharu Fujieda13. 1. Chiba University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. Electronic address: yokamoto@faculty.chiba-u.jp. 2. Yamagata University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 3. Okayama University, Department of Otorhinolaryngology, Japan. 4. Saitama Medical University, Department of Otorhinolaryngology/Allergy Center, Japan. 5. Nippon Medical School, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 6. Nagoya City University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 7. Hiroshima University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 8. Osaka Medical University, Department of Otorhinolaryngology, Japan. 9. Chiba University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 10. Iida Hospital, Departments of Otorhinolaryngology and Allergology, Japan. 11. Akita University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 12. Nippon Medical School, Department of Otorhinolaryngology, Musashikosugi Hospital, Japan. 13. University of Fukui, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. 14. Yuta Clinic, Japan. 15. Department of Health Informatics, Kyoto University School of Public Health, Japan.
Abstract
OBJECTIVE: In anticipation of the development of guidelines for antigen-specific subcutaneous immunotherapy (SCIT), we present recommendations that can serve as guiding principles based on a review of the scientific literature. METHODS: Clinical questions (CQs) concerning SCIT were prepared. Literature searches for publications between January 1990 and February 2011 were performed in PubMed, the Cochrane Library, and Japana Centra Revuo Medicina Web version 4. Qualified studies were analyzed and the results were evaluated, consolidated, and codified. RESULTS: We present answers for 13 CQs on the indications, methods, effectiveness and mechanisms of SCIT, with evidence-based recommendations. CONCLUSION: The guiding principles are intended to be applied to children (≤15 years old) and adults (≥16 years old) with allergic rhinitis (AR). These principles can be used by otorhinolaryngologists for diagnosis of AR, evaluation of severity and rhinoscopic findings, performance of antigen challenge tests, and management of systemic anaphylactic reactions associated with SCIT.
OBJECTIVE: In anticipation of the development of guidelines for antigen-specific subcutaneous immunotherapy (SCIT), we present recommendations that can serve as guiding principles based on a review of the scientific literature. METHODS: Clinical questions (CQs) concerning SCIT were prepared. Literature searches for publications between January 1990 and February 2011 were performed in PubMed, the Cochrane Library, and Japana Centra Revuo Medicina Web version 4. Qualified studies were analyzed and the results were evaluated, consolidated, and codified. RESULTS: We present answers for 13 CQs on the indications, methods, effectiveness and mechanisms of SCIT, with evidence-based recommendations. CONCLUSION: The guiding principles are intended to be applied to children (≤15 years old) and adults (≥16 years old) with allergic rhinitis (AR). These principles can be used by otorhinolaryngologists for diagnosis of AR, evaluation of severity and rhinoscopic findings, performance of antigen challenge tests, and management of systemic anaphylactic reactions associated with SCIT.