Literature DB >> 241832

Intestinal pH as a factor in selection of animal models for bioavailability testing.

W G Crouthamel, C R Abolin, J Hsieh, J K Lim.   

Abstract

Previous in situ studies showed that intestinal drug absorption is strongly influenced by intestinal pH. Three animal species considered for bioavailability testing were studied in situ to determine intestinal pH. Results from the rat and dog correlated well with results in humans, while results from the rabbit did not. The rabbit appears to be a poor candidate for attempted animal-human bioavailability correlations.

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Year:  1975        PMID： 241832     DOI： 10.1002/jps.2600641036

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  5 in total

1.  Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis.

Authors:  Sheila Annie Peters
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

2.  Evidence for site-specific absorption of a novel ACE inhibitor.

Authors:  G M Grass; W T Morehead
Journal:  Pharm Res       Date:  1989-09       Impact factor: 4.200

Review 3.  Classical absorption theory and the development of gastric mucosal damage associated with the non-steroidal anti-inflammatory drugs.

Authors:  K McCormack; K Brune
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

4.  Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration-time profiles in rat.

Authors:  Sheila Annie Peters; Leif Hultin
Journal:  J Pharmacokinet Pharmacodyn       Date:  2007-10-26       Impact factor: 2.745

5.  Apparent dose-dependent absorption of chlorothiazide in dogs.

Authors:  D E Resetarits; T R Bates
Journal:  J Pharmacokinet Biopharm       Date:  1979-10
  5 in total

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