Xu Chen1, Yulan Yan, Ping Li, Zheng Yang, Lingyan Qin, Wuning Mo. 1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. Electronic address: chenxu16300@163.com.
Abstract
OBJECTIVES: In view of the controversies surrounding the association of glutathione S-transferases (GST) P1 with endometriosis, a meta-analysis of GSTP1 -313A/G polymorphism with endometriosis risk was performed. STUDY DESIGN: The relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct and Chinese Biomedical Literature Database (CBM) until March 2013. The association between GSTP1 -313A/G polymorphism and endometriosis risk was pooled by odds ratios (ORs) together with their 95% confidence intervals (95% CIs). RESULTS: A total of eight case-control studies were eventually identified. We found that GSTP1-313A/G polymorphism was not associated with endometriosis risk in the overall population (A vs. G: OR=1.02, 95% CI=0.97-1.07, P=0.511; AA vs. GG: OR=1.02, 95% CI=0.98-1.06, P=0.359; GA vs. GG: OR=1.03, 95% CI=0.98-1.08, P=0.299; AA vs. GA/GG: OR=1.01, 95% CI=0.96-1.07, P=0.621; AA/GA vs. GG: OR=1.00, 95% CI=0.97-1.03, P=0.972). In the sub-group analysis based on ethnicity, a significant association was found in Caucasians under the recessive model (AA vs. GA/GG: OR=1.28, 95% CI=1.08-1.53, P=0.006). CONCLUSIONS: GSTP1 -313A/G polymorphism may not be associated with endometriosis risk, while the observed increase in risk of endometriosis may be due to small-study bias. Considering the limited sample size and ethnicity included in our meta-analysis, an updated meta-analysis will be urgently needed when further larger and well-designed studies are published. Crown
OBJECTIVES: In view of the controversies surrounding the association of glutathione S-transferases (GST) P1 with endometriosis, a meta-analysis of GSTP1-313A/G polymorphism with endometriosis risk was performed. STUDY DESIGN: The relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct and Chinese Biomedical Literature Database (CBM) until March 2013. The association between GSTP1-313A/G polymorphism and endometriosis risk was pooled by odds ratios (ORs) together with their 95% confidence intervals (95% CIs). RESULTS: A total of eight case-control studies were eventually identified. We found that GSTP1-313A/G polymorphism was not associated with endometriosis risk in the overall population (A vs. G: OR=1.02, 95% CI=0.97-1.07, P=0.511; AA vs. GG: OR=1.02, 95% CI=0.98-1.06, P=0.359; GA vs. GG: OR=1.03, 95% CI=0.98-1.08, P=0.299; AA vs. GA/GG: OR=1.01, 95% CI=0.96-1.07, P=0.621; AA/GA vs. GG: OR=1.00, 95% CI=0.97-1.03, P=0.972). In the sub-group analysis based on ethnicity, a significant association was found in Caucasians under the recessive model (AA vs. GA/GG: OR=1.28, 95% CI=1.08-1.53, P=0.006). CONCLUSIONS:GSTP1-313A/G polymorphism may not be associated with endometriosis risk, while the observed increase in risk of endometriosis may be due to small-study bias. Considering the limited sample size and ethnicity included in our meta-analysis, an updated meta-analysis will be urgently needed when further larger and well-designed studies are published. Crown