Literature DB >> 24183011

Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology.

Steven A McCarroll1, Steven E Hyman.   

Abstract

Advances in genome analysis, accompanied by the assembly of large patient cohorts, are making possible successful genetic analyses of polygenic brain disorders. If the resulting molecular clues, previously hidden in the genomes of affected individuals, are to yield useful information about pathogenesis and inform the discovery of new treatments, neurobiology will have to rise to many difficult challenges. Here we review the underlying logic of the genetic investigations, describe in more detail progress in schizophrenia and autism, and outline the challenges for neurobiology that lie ahead. We argue that technologies at the disposal of neuroscience are adequately advanced to begin to study the biology of common and devastating polygenic disorders.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2013        PMID： 24183011      PMCID： PMC4066986          DOI： 10.1016/j.neuron.2013.10.046

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  61 in total

Review 1.  Animal models of neuropsychiatric disorders.

Authors:  Eric J Nestler; Steven E Hyman
Journal:  Nat Neurosci       Date:  2010-09-27       Impact factor: 24.884

2.  Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

Authors:  Stephan J Sanders; A Gulhan Ercan-Sencicek; Vanessa Hus; Rui Luo; Michael T Murtha; Daniel Moreno-De-Luca; Su H Chu; Michael P Moreau; Abha R Gupta; Susanne A Thomson; Christopher E Mason; Kaya Bilguvar; Patricia B S Celestino-Soper; Murim Choi; Emily L Crawford; Lea Davis; Nicole R Davis Wright; Rahul M Dhodapkar; Michael DiCola; Nicholas M DiLullo; Thomas V Fernandez; Vikram Fielding-Singh; Daniel O Fishman; Stephanie Frahm; Rouben Garagaloyan; Gerald S Goh; Sindhuja Kammela; Lambertus Klei; Jennifer K Lowe; Sabata C Lund; Anna D McGrew; Kyle A Meyer; William J Moffat; John D Murdoch; Brian J O'Roak; Gordon T Ober; Rebecca S Pottenger; Melanie J Raubeson; Youeun Song; Qi Wang; Brian L Yaspan; Timothy W Yu; Ilana R Yurkiewicz; Arthur L Beaudet; Rita M Cantor; Martin Curland; Dorothy E Grice; Murat Günel; Richard P Lifton; Shrikant M Mane; Donna M Martin; Chad A Shaw; Michael Sheldon; Jay A Tischfield; Christopher A Walsh; Eric M Morrow; David H Ledbetter; Eric Fombonne; Catherine Lord; Christa Lese Martin; Andrew I Brooks; James S Sutcliffe; Edwin H Cook; Daniel Geschwind; Kathryn Roeder; Bernie Devlin; Matthew W State
Journal:  Neuron       Date:  2011-06-09       Impact factor: 17.173

3.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

Review 4.  The development and application of optogenetics.

Authors:  Lief Fenno; Ofer Yizhar; Karl Deisseroth
Journal:  Annu Rev Neurosci       Date:  2011       Impact factor: 12.449

Review 5.  Autism spectrum disorders and autistic traits: a decade of new twin studies.

Authors:  Angelica Ronald; Rosa A Hoekstra
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2011-01-13       Impact factor: 3.568

6.  A map of human genome variation from population-scale sequencing.

Authors:  Gonçalo R Abecasis; David Altshuler; Adam Auton; Lisa D Brooks; Richard M Durbin; Richard A Gibbs; Matt E Hurles; Gil A McVean
Journal:  Nature       Date:  2010-10-28       Impact factor: 49.962

7.  Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.

Authors:  João Peça; Cátia Feliciano; Jonathan T Ting; Wenting Wang; Michael F Wells; Talaignair N Venkatraman; Christopher D Lascola; Zhanyan Fu; Guoping Feng
Journal:  Nature       Date:  2011-03-20       Impact factor: 49.962

8.  The architecture of gene regulatory variation across multiple human tissues: the MuTHER study.

Authors:  Alexandra C Nica; Leopold Parts; Daniel Glass; James Nisbet; Amy Barrett; Magdalena Sekowska; Mary Travers; Simon Potter; Elin Grundberg; Kerrin Small; Asa K Hedman; Veronique Bataille; Jordana Tzenova Bell; Gabriela Surdulescu; Antigone S Dimas; Catherine Ingle; Frank O Nestle; Paola di Meglio; Josine L Min; Alicja Wilk; Christopher J Hammond; Neelam Hassanali; Tsun-Po Yang; Stephen B Montgomery; Steve O'Rahilly; Cecilia M Lindgren; Krina T Zondervan; Nicole Soranzo; Inês Barroso; Richard Durbin; Kourosh Ahmadi; Panos Deloukas; Mark I McCarthy; Emmanouil T Dermitzakis; Timothy D Spector
Journal:  PLoS Genet       Date:  2011-02-03       Impact factor: 5.917

9.  Mapping and analysis of chromatin state dynamics in nine human cell types.

Authors:  Jason Ernst; Pouya Kheradpour; Tarjei S Mikkelsen; Noam Shoresh; Lucas D Ward; Charles B Epstein; Xiaolan Zhang; Li Wang; Robbyn Issner; Michael Coyne; Manching Ku; Timothy Durham; Manolis Kellis; Bradley E Bernstein
Journal:  Nature       Date:  2011-03-23       Impact factor: 49.962

10.  Discovery and genotyping of genome structural polymorphism by sequencing on a population scale.

Authors:  Robert E Handsaker; Joshua M Korn; James Nemesh; Steven A McCarroll
Journal:  Nat Genet       Date:  2011-02-13       Impact factor: 38.330
View more
  34 in total

Review 1.  Genomic perspectives of transcriptional regulation in forebrain development.

Authors:  Alex S Nord; Kartik Pattabiraman; Axel Visel; John L R Rubenstein
Journal:  Neuron       Date:  2015-01-07       Impact factor: 17.173

Review 2.  Adult Hippocampal Neurogenesis, Fear Generalization, and Stress.

Authors:  Antoine Besnard; Amar Sahay
Journal:  Neuropsychopharmacology       Date:  2015-06-12       Impact factor: 7.853

3.  Perspective: Revealing molecular secrets.

Authors:  Steven E Hyman
Journal:  Nature       Date:  2014-04-03       Impact factor: 49.962

Review 4.  One gene, many neuropsychiatric disorders: lessons from Mendelian diseases.

Authors:  Xiaolin Zhu; Anna C Need; Slavé Petrovski; David B Goldstein
Journal:  Nat Neurosci       Date:  2014-05-27       Impact factor: 24.884

Review 5.  Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.

Authors:  A Devor; O A Andreassen; Y Wang; T Mäki-Marttunen; O B Smeland; C-C Fan; A J Schork; D Holland; W K Thompson; A Witoelar; C-H Chen; R S Desikan; L K McEvoy; S Djurovic; P Greengard; P Svenningsson; G T Einevoll; A M Dale
Journal:  Mol Psychiatry       Date:  2017-03-28       Impact factor: 15.992

Review 6.  Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops.

Authors:  Caitlin Mullins; Gord Fishell; Richard W Tsien
Journal:  Neuron       Date:  2016-03-16       Impact factor: 17.173

7.  Schizophrenia and the neurodevelopmental continuum:evidence from genomics.

Authors:  Michael J Owen; Michael C O'Donovan
Journal:  World Psychiatry       Date:  2017-10       Impact factor: 49.548

Review 8.  Modeling autism in non-human primates: Opportunities and challenges.

Authors:  Hui Zhao; Yong-Hui Jiang; Yong Q Zhang
Journal:  Autism Res       Date:  2018-03-23       Impact factor: 5.216

9.  Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.

Authors:  David J Tischfield; Dave K Saraswat; Andrew Furash; Stephen C Fowler; Marc V Fuccillo; Stewart A Anderson
Journal:  Neurobiol Dis       Date:  2017-04-19       Impact factor: 5.996

10.  New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia.

Authors:  Avia Merenlender-Wagner; Zeev Shemer; Olga Touloumi; Roza Lagoudaki; Eliezer Giladi; Annie Andrieux; Nikolaos C Grigoriadis; Illana Gozes
Journal:  Autophagy       Date:  2014       Impact factor: 16.016
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.