Brain and lung involvement of mycosis fungoides demonstrated by radionuclide imaging.

A patient with advanced mycosis fungoides developed neurologic and respiratory symptoms and signs following multiple courses of chemotherapy and radiotherapy. Various repeated diagnostic procedures--including cranial computerized tomography and fiberoptic bronchoscopy with transbronchial lung biopsy--failed to demonstrate an unusual involvement of the brain and lungs by mycosis fungoides. Radionuclide brain imaging and gallium imaging of the lungs demonstrated diffuse lesions confirmed at autopsy.