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Literature DB >> 2417957

Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.

E Piccolella, G Lombardi, D Vismara, F Del Gallo, V Colizzi, A Dolei, F Dianzani.

Abstract

Dexamethasone inhibits the expression of the interleukin-2 receptor, the synthesis of immune interferon, and the development of natural killer cells when added to peripheral blood mononuclear cells cultured with soluble microbial antigens (purified protein derivative and a polysaccharide extract from Candida albicans [MPPS]) or human recombinant interleukin-2.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1986 PMID： 2417957 PMCID： PMC262419 DOI： 10.1128/iai.51.2.712-714.1986

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

20 in total

1. Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

Authors: S Gillis; G R Crabtree; K A Smith
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

2. Induction of proliferation in vitro of resting human natural killer cells: expression of surface activation antigens.

Authors: L London; B Perussia; G Trinchieri
Journal: J Immunol Date: 1985-02 Impact factor: 5.422

3. Candida albicans polysaccharide extract (MPPS) and PPD stimulate the production of interleukin-1 and lymphocyte proliferation.

Authors: G Lombardi; E Piccolella; D Vismara; V Colizzi; G L Asherson
Journal: Clin Exp Immunol Date: 1984-12 Impact factor: 4.330

4. Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).

Authors: K Itoh; K Shiiba; Y Shimizu; R Suzuki; K Kumagai
Journal: J Immunol Date: 1985-05 Impact factor: 5.422

5. Regulation by interleukin 2 of interleukin 2 receptors and gamma-interferon synthesis by human thymocytes: augmentation of interleukin 2 receptors by interleukin 2.

Authors: G H Reem; N H Yeh
Journal: J Immunol Date: 1985-02 Impact factor: 5.422

4. Non-major histocompatibility complex-restricted cytotoxic activity of blood mononuclear cells stimulated with secreted mycobacterial proteins and other mycobacterial antigens.

Authors: P Ravn; B K Pedersen
Journal: Infect Immun Date: 1994-12 Impact factor: 3.441

5. Gamma interferon is produced by human natural killer cells but not T cells during Staphylococcus aureus stimulation.

Authors: R Yoshihara; S Shiozawa; T Fujita; K Chihara
Journal: Infect Immun Date: 1993-08 Impact factor: 3.441

5 in total

Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.

1. Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

2. Induction of proliferation in vitro of resting human natural killer cells: expression of surface activation antigens.

3. Candida albicans polysaccharide extract (MPPS) and PPD stimulate the production of interleukin-1 and lymphocyte proliferation.

4. Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).

5. Regulation by interleukin 2 of interleukin 2 receptors and gamma-interferon synthesis by human thymocytes: augmentation of interleukin 2 receptors by interleukin 2.

6. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

7. Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.

8. Modulation of human natural killer cell activity by recombinant human interleukin 2.

9. Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

10. Response of resting human peripheral blood natural killer cells to interleukin 2.

1. Cytotoxic activity of human lymphocytes against differentiated intestinal tumour cell lines.

2. Dexamethasone exacerbates cytotoxic chemotherapy induced lethargy and weight loss in female tumor free mice.

3. Cytotoxic activity of intestinal lamina propria lymphocytes on human immunodeficiency virus (HIV)-infected cells.

4. Non-major histocompatibility complex-restricted cytotoxic activity of blood mononuclear cells stimulated with secreted mycobacterial proteins and other mycobacterial antigens.

5. Gamma interferon is produced by human natural killer cells but not T cells during Staphylococcus aureus stimulation.