Literature DB >> 24179

Structural evidence for gene duplication in the evolution of the acid proteases.

J Tang, M N James, I N Hsu, J A Jenkins, T L Blundell.   

Abstract

X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented.

Mesh：

Substances：

Year:  1978        PMID： 24179     DOI： 10.1038/271618a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  68 in total

1.  Accommodation of a highly symmetric core within a symmetric protein superfold.

Authors:  Stephen R Brych; Jaewon Kim; Timothy M Logan; Michael Blaber
Journal:  Protein Sci       Date:  2003-12       Impact factor: 6.725

2.  Celebrating structural biology.

Authors: 
Journal:  Nat Struct Mol Biol       Date:  2011-12-05       Impact factor: 15.369

3.  Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.

Authors:  Jihun Lee; Michael Blaber
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

4.  Evolution of a protein folding nucleus.

Authors:  Xue Xia; Liam M Longo; Mason A Sutherland; Michael Blaber
Journal:  Protein Sci       Date:  2015-12-10       Impact factor: 6.725

5.  Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2.

Authors:  Judith A Woodfolk; Jill Glesner; Paul W Wright; Christopher L Kepley; Mi Li; Martin Himly; Lyndsey M Muehling; Alla Gustchina; Alexander Wlodawer; Martin D Chapman; Anna Pomés
Journal:  J Biol Chem       Date:  2015-12-07       Impact factor: 5.157

6.  Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.

Authors:  Mi Li; Alla Gustchina; Rui Cruz; Marisa Simões; Pedro Curto; Juan Martinez; Carlos Faro; Isaura Simões; Alexander Wlodawer
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-09-30

7.  Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases.

Authors:  D D Loeb; C A Hutchison; M H Edgell; W G Farmerie; R Swanstrom
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

8.  Identification of active sites in amidase: evolutionary relationship between amide bond- and peptide bond-cleaving enzymes.

Authors:  M Kobayashi; Y Fujiwara; M Goda; H Komeda; S Shimizu
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

9.  Inherent chaperone-like activity of aspartic proteases reveals a distant evolutionary relation to double-psi barrel domains of AAA-ATPases.

Authors:  Michael Hulko; Andrei N Lupas; Jörg Martin
Journal:  Protein Sci       Date:  2007-04       Impact factor: 6.725

10.  A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.

Authors:  D Bailey; J B Cooper
Journal:  Protein Sci       Date:  1994-11       Impact factor: 6.725
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