Literature DB >> 2417885

cAMP mediated proteolysis of the catalytic subunit of cAMP-dependent protein kinase.

B A Hemmings.   

Abstract

The cAMP-dependent protein kinase from LLC-PK1 cells can be activated in vivo by calcitonin and vasopressin, or forskolin. Continuous treatment of cells with these agents results in a decrease of total cAMP-PK activity. The loss of kinase activity was enhanced when either of these three agents was incubated in the presence of isobutylmethylxanthine. Results obtained using affinity purified antibodies to the catalytic subunit show that the loss of kinase was due to specific proteolysis of this subunit.

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Year:  1986        PMID： 2417885     DOI： 10.1016/0014-5793(86)80226-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Dependence of urokinase-type-plasminogen-activator induction on cyclic AMP-dependent protein kinase activation in LLC-PK1 cells.

Authors:  D A Jans; T J Resink; B A Hemmings
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

2.  Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation.

Authors:  Jon R Fee; Dennis R Sparta; Darin J Knapp; George R Breese; Mitchell J Picker; Todd E Thiele
Journal:  Alcohol Clin Exp Res       Date:  2004-10       Impact factor: 3.455

3.  Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men.

Authors:  Kimberly A Burton; Deborah A McDermott; David Wilkes; Melissa N Poulsen; Michael A Nolan; Marc Goldstein; Craig T Basson; G Stanley McKnight
Journal:  Mol Endocrinol       Date:  2006-05-25

4.  Regulation of cyclic AMP-dependent protein kinase levels during skeletal myogenesis.

Authors:  I A Lorimer; B D Sanwal
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857

5.  Selective regulation of the amount of catalytic subunit of cyclic AMP-dependent protein kinases during isoprenaline-induced growth of the rat parotid gland.

Authors:  G Schwoch
Journal:  Biochem J       Date:  1987-11-15       Impact factor: 3.857

6.  Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region.

Authors:  X Xu; D A Brown; I Kitajima; J Bilakovics; L W Fey; M I Nerenberg
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

7.  Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.

Authors:  N Masson; M Ellis; S Goodbourn; K A Lee
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

8.  Okadaic acid induction of the urokinase-type plasminogen activator gene occurs independently of cAMP-dependent protein kinase and protein kinase C and is sensitive to protein synthesis inhibition.

Authors:  Y Nagamine; A Ziegler
Journal:  EMBO J       Date:  1991-01       Impact factor: 11.598

9.  β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.

Authors:  Kelly A Kaihara; Lorna M Dickson; David A Jacobson; Natalia Tamarina; Michael W Roe; Louis H Philipson; Barton Wicksteed
Journal:  Diabetes       Date:  2013-01-24       Impact factor: 9.461

10.  Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus.

Authors:  G Houge; Y S Cho-Chung; S O Døskeland
Journal:  Br J Cancer       Date:  1992-12       Impact factor: 7.640
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