Literature DB >> 24178542

Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells.

D Ghigo1, D Geromin, C Franchino, R Todde, C Priotto, C Costamagna, M Arese, G Garbarino, G P Pescarmona, A Bosia.   

Abstract

The synthesis of nitric oxide (NO), detected as citrulline production, in human (HUVEC) and murine (tEnd.1) endothelial cells correlated with intracellular GSH. tEnd.1, which exhibited an intracellular GSH level 2.5-fold higher than HUVEC, showed a citrulline production (basally and after ionomycin stimulation) 5-8 times higher than human cells. Ionomycinelicited citrulline synthesis in tEnd.1 cells increased 2.4-fold after loading with GSH, and decreased dose-dependently after GSH depletion. Cell loading with N-(2-mercaptopropionyl)-glycine neither significantly increased citrulline production nor relieved the effect of GSH depletion.

Entities:  

Year:  1996        PMID： 24178542     DOI： 10.1007/BF00807330

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  9 in total

Review 1.  Nitric oxide synthases: roles, tolls, and controls.

Authors:  C Nathan; Q W Xie
Journal:  Cell       Date:  1994-09-23       Impact factor: 41.582

2.  Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene.

Authors:  R L Williams; S A Courtneidge; E F Wagner
Journal:  Cell       Date:  1988-01-15       Impact factor: 41.582

Review 4.  NO at work.

Authors:  H H Schmidt; U Walter
Journal:  Cell       Date:  1994-09-23       Impact factor: 41.582

5.  Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells.

Authors:  D Ghigo; P Alessio; A Foco; F Bussolino; C Costamagna; R Heller; G Garbarino; G P Pescarmona; A Bosia
Journal:  Am J Physiol       Date:  1993-09

Review 6.  Biochemistry of nitric oxide and its redox-activated forms.

Authors:  J S Stamler; D J Singel; J Loscalzo
Journal:  Science       Date:  1992-12-18       Impact factor: 47.728

7.  Effect of GSH depletion by 1-chloro-2,4-dinitrobenzene on human platelet aggregation, arachidonic acid oxidative metabolism and cytoskeletal proteins.

Authors:  A Bosia; P Spangenberg; D Ghigo; R Heller; W Lösche; G P Pescarmona; U Till
Journal:  Thromb Res       Date:  1985-02-01       Impact factor: 3.944

8.  Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

Authors:  J M Griscavage; J M Fukuto; Y Komori; L J Ignarro
Journal:  J Biol Chem       Date:  1994-08-26       Impact factor: 5.157

9.  Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.

Authors:  D Ghigo; M Arese; R Todde; A Vecchi; F Silvagno; C Costamagna; Q G Dong; M Alessio; R Heller; R Soldi; F Trucco; G Garbarino; G Pescarmona; A Mantovani; F Bussolino; A Bosia
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307
  9 in total
  3 in total

1.  Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photorelaxation.

Authors:  I L Megson; S A Holmes; K S Magid; R J Pritchard; F W Flitney
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

2.  Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis.

Authors:  Sarah McKinley-Barnard; Tom Andre; Masahiko Morita; Darryn S Willoughby
Journal:  J Int Soc Sports Nutr       Date:  2015-06-10       Impact factor: 5.150

3.  Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats.

Authors:  Moustafa Mahmoud Hamdy; Mahran S Abdel-Rahman; Dalia M Badary; Mahmoud S Sabra
Journal:  Eur J Med Res       Date:  2022-07-11       Impact factor: 4.981
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.