| Literature DB >> 24178362 |
Jessica R Keys1, Peter A Leone, Joseph J Eron, Kelcie Alexander, Myra Brinson, Ronald Swanstrom.
Abstract
North Carolina locates acute HIV cases by pooled nucleic acid testing of HIV-antibody negative serum samples. Here, 224 pools of 80 HIV-negative samples (N = 17,920) were screened for viral RNA from HCV, GBV-C, and influenza A. No evidence of influenza A was found, but HCV and GBV-C were common (1.2% and 1.7% prevalence, respectively), demonstrating the utility of pooled testing in locating individuals that may remain undiagnosed otherwise. By sequencing positive pools, potential transmission clusters may be located as well.Entities:
Keywords: GB virus C; acute HIV infection; emerging pathogens; hepatitis C virus; influenza A; public health
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Year: 2013 PMID: 24178362 PMCID: PMC3947266 DOI: 10.1002/jmv.23829
Source DB: PubMed Journal: J Med Virol ISSN: 0146-6615 Impact factor: 2.327