Literature DB >> 24177528

Drug resistance in the fission yeast Schizosaccharomyces pombe: pleiotropic mutations affecting the oleic acid and sterol composition of cell membranes.

P A Johnston1, A Coddington.   

Abstract

The whole cell lipid and sterol content of the drug resistant strains cyh1, cyh3 and cyh4 was compared with that of wild type by thin layer and gas liquid chromatography and by UV spectrophotometric analysis. The cyh3 and cyh4 strains had a decreased content of the unsaturated 18:1 fatty acid oleic acid, a decreased content of ergosterol and an increased content of 24,28 dehydroergosterol with respect to wild type. The cyh1 strain, however, only showed a decreased content of ergosterol and an increased content of 24,28 dehydro-ergosterol when compared to wild type.

Entities:  

Year:  1984        PMID： 24177528     DOI： 10.1007/BF00405430

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  12 in total

1.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

Review 2.  Lipids of yeasts.

Authors:  J B Rattray; A Schibeci; D K Kidby
Journal:  Bacteriol Rev       Date:  1975-09

3.  Neutral lipids in the cells and cell envelope fractions of aerobic baker's yeast and anaerobic brewer's yeast.

Authors:  T Nurminen; K Konttinen; H Suomalainen
Journal:  Chem Phys Lipids       Date:  1975-02       Impact factor: 3.329

4.  Characterisation of the ribosomal proteins from Schizosaccharomyces pombe by two-dimensional polyacrylamide gel electrophoresis: demonstration that a cycloheximide resistant strain, cyh1, has an altered 60S ribosomal protein.

Authors:  A Coddington; R Fluri
Journal:  Mol Gen Genet       Date:  1977-12-14

5.  Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: evidence for the existence of pleiotropic mutations affecting dependent transport systems.

Authors:  P A Johnston; A Coddington
Journal:  Mol Gen Genet       Date:  1982

6.  Biogenesis of mitochondria. The effects of altered membrane lipid composition on cation transport by mitochondria of Saccharomyces cerevisiae.

Authors:  J M Haslam; T W Spithill; A W Linnane; J B Chappell
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

7.  The effect of altered ergosterol content on the transport of various amino acids in Candida albicans.

Authors:  M Singh; A Jayakumar; R Prasad
Journal:  Biochim Biophys Acta       Date:  1979-07-19

8.  Genetic studies on cycloheximide-resistant strains of Schizosaccharomyces pombe.

Authors:  M A Ibrahim; A Coddington
Journal:  Heredity (Edinb)       Date:  1976-10       Impact factor: 3.821

9.  Phosphatidic acid and phosphatidylinositol metabolism in Schizosaccharomyces pombe.

Authors:  G L White; J N Hawthorne
Journal:  Biochem J       Date:  1970-04       Impact factor: 3.857

10.  Nystatin-resistant mutants of yeast: alterations in sterol content.

Authors:  R A Woods
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490
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