Claudio Pelucchi1, Carlotta Galeone, Jerry Polesel, Marco Manzari, Antonella Zucchetto, Renato Talamini, Silvia Franceschi, Eva Negri, Carlo La Vecchia. 1. From the *Dipartimento di Epidemiologia, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri; †Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan; ‡S.O.C. di Epidemiologia e Biostatistica, IRCCS-Centro di Riferimento Oncologico, Aviano (PN); §Dipartimento di Traumatologia, Ortopedia e Medicina del Lavoro, Università degli Studi di Torino, Turin, Italy; and ∥International Agency for Research on Cancer, Lyon, France.
Abstract
OBJECTIVE: The objective of this study was to provide further information on the role of personal characteristics and lifestyle factors, including obesity, diabetes, and tobacco smoking, on survival from pancreatic cancer. METHODS: We obtained follow-up data of pancreatic cancer patients enrolled in 2 Italian case-control studies. Information on characteristics and habits up to the time of diagnosis was collected by trained interviewers. Vital status was ascertained through population registers and record linkage with health system databases. Hazard ratios (HRs) of all-cause mortality and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. RESULTS: Follow-up information was retrieved for 648 cancer patients. Compared with subjects with body mass index of less than 25 kg/m, the HRs were 1.14 (95% CI, 0.94-1.39) for overweight (ie, 25-29.9 kg/m) and 1.32 (95% CI, 0.98-1.79) for obese (ie, ≥30 kg/m) patients (trend P = 0.046). The HRs were 1.37 (95% CI, 1.14-1.65) for ever, 1.30 (95% CI, 1.03-1.65) for ex-smokers, and 1.42 (95% CI, 1.16-1.73) for current versus never smokers. Increasing amount and duration of smoking were associated with reduced survival after pancreatic cancer. No association emerged with diabetes, alcohol consumption, and diet. CONCLUSIONS: Smoking and overweight before diagnosis may play a role in the prognosis of pancreatic cancer, besides its etiology.
OBJECTIVE: The objective of this study was to provide further information on the role of personal characteristics and lifestyle factors, including obesity, diabetes, and tobacco smoking, on survival from pancreatic cancer. METHODS: We obtained follow-up data of pancreatic cancerpatients enrolled in 2 Italian case-control studies. Information on characteristics and habits up to the time of diagnosis was collected by trained interviewers. Vital status was ascertained through population registers and record linkage with health system databases. Hazard ratios (HRs) of all-cause mortality and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. RESULTS: Follow-up information was retrieved for 648 cancerpatients. Compared with subjects with body mass index of less than 25 kg/m, the HRs were 1.14 (95% CI, 0.94-1.39) for overweight (ie, 25-29.9 kg/m) and 1.32 (95% CI, 0.98-1.79) for obese (ie, ≥30 kg/m) patients (trend P = 0.046). The HRs were 1.37 (95% CI, 1.14-1.65) for ever, 1.30 (95% CI, 1.03-1.65) for ex-smokers, and 1.42 (95% CI, 1.16-1.73) for current versus never smokers. Increasing amount and duration of smoking were associated with reduced survival after pancreatic cancer. No association emerged with diabetes, alcohol consumption, and diet. CONCLUSIONS: Smoking and overweight before diagnosis may play a role in the prognosis of pancreatic cancer, besides its etiology.
Authors: Christie Y Jeon; Donghui Li; Sean Cleary; Rachael Stolzenberg-Solomon; Cristina Bosetti; Carlo La Vecchia; Miquel Porta; Adetunji T Toriola; Rayjean J Hung; Robert C Kurtz; Sara H Olson Journal: Pancreas Date: 2018-03 Impact factor: 3.327
Authors: Donghui Li; Yixiang Mao; Ping Chang; Chang Liu; Manal M Hassan; Saiching J Yeung; James L Abbruzzese Journal: Am J Cancer Res Date: 2015-09-15 Impact factor: 6.166
Authors: Chen Yuan; Vicente Morales-Oyarvide; Ana Babic; Clary B Clish; Peter Kraft; Ying Bao; Zhi Rong Qian; Douglas A Rubinson; Kimmie Ng; Edward L Giovannucci; Shuji Ogino; Meir J Stampfer; John Michael Gaziano; Howard D Sesso; Barbara B Cochrane; JoAnn E Manson; Charles S Fuchs; Brian M Wolpin Journal: J Clin Oncol Date: 2017-03-30 Impact factor: 44.544
Authors: William H Jin; Eric A Mellon; Jessica M Frakes; Gilbert Z Murimwa; Pamela J Hodul; Jose M Pimiento; Mokenge P Malafa; Sarah E Hoffe Journal: J Gastrointest Oncol Date: 2018-02