Literature DB >> 24176891

Resveratrol stabilized gold nanoparticles enable surface loading of doxorubicin and anticancer activity.

Ranjeet Kumar Mohanty1, Sathiah Thennarasu1, Asit Baran Mandal2.   

Abstract

The green synthesis of gold nanoparticles was achieved by exploiting the antioxidant property of resveratrol (R). The formation of resveratrol stabilized gold nanoparticles (R-GNPs) was confirmed by the observation of the surface plasmon resonance band at 537 nm. The average size of R-GNPs produced in resveratrol medium was ~35nm. The geometrical shape and zeta potential of the gold nanoparticles were spherical and -21.2 mV, respectively. R-GNPs showed excellent stability in saline and other buffers mimicking the physiological pH. The MTT assay using fibroblast cells from explants tissue revealed the biocompatibility of R-GNPs. The cytotoxic activity of doxorubicin loaded R-GNPs against glioma carcinoma cell line (LN 229), showed the suitability of R-GNPs as a carrier for anticancer drugs.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anticancer activity; Doxorubicin; Gold nanoparticles; Resveratrol

Mesh：

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Year:  2013        PMID： 24176891     DOI： 10.1016/j.colsurfb.2013.09.057

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


  6 in total

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  6 in total

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