Literature DB >> 24176398

Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives.

Leyla Yurttaş1, Murat Duran, Şeref Demirayak, Hülya Karaca Gençer, Yağmur Tunalı.   

Abstract

In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anticancer; Antimicrobial; Brine-Shrimp test; Imidazole

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Year:  2013        PMID： 24176398     DOI： 10.1016/j.bmcl.2013.10.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Sequential MCR via Staudinger/Aza-Wittig versus Cycloaddition Reaction to Access Diversely Functionalized 1-Amino-1H-Imidazole-2(3H)-Thiones.

Authors:  Cecilia Ciccolini; Giacomo Mari; Gianfranco Favi; Fabio Mantellini; Lucia De Crescentini; Stefania Santeusanio
Journal:  Molecules       Date:  2019-10-21       Impact factor: 4.411

2.  Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies.

Authors:  Helen Oluwatola Omoregie; Oluwakemi A Oloba-Whenu; Olawale J Olowu; Tolulope M Fasina; Alexandra Friedrich; Martin Haehnel; Todd B Marder
Journal:  RSC Adv       Date:  2022-08-17       Impact factor: 4.036

3.  Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides.

Authors:  Xiaobin Wang; Zhengjiao Ren; Mengqi Wang; Min Chen; Aiming Lu; Weijie Si; Chunlong Yang
Journal:  Chem Cent J       Date:  2018-07-17       Impact factor: 4.215
  3 in total

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