AIMS: Stereotactic body radiotherapy (SBRT) is commonly considered an important treatment option for patients with stage I non-small cell lung cancer (NSCLC) who have contraindications for surgery or refuse surgery. Many studies have reported that the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) of the primary tumor has prognostic value for resected NSCLC. The purpose of this study was to determine whether SUVmax is a predictor of disease-free survival (DFS) in patients with stage I NSCLC after SBRT. METHODS: In all patients, the diagnosis was pathologically or cytologically confirmed. The prescription dose was 48 Gy in four fractions at the isocenter. FDG-PET was performed before SBRT. RESULTS: Twenty-nine patients were enrolled in this study. The median follow-up period was 14 months (range, 2-56 months). Regional lymph node metastasis and distant metastasis were observed in 5 (17%) and 2 (7%), respectively. The median SUVmax was 5.6 (range, 2.2-22.0). DFS at 2 years was significantly different between the low SUVmax (<8.0) and high SUVmax (≥8.0) groups (85 versus 17%). In univariate analysis, SUVmax and gross tumor volume were significantly correlated with DFS. Multivariate analysis included variables with P-values <0.20 and showed that only SUVmax was significantly correlated with DFS. CONCLUSION: Pretreatment SUVmax on FDG-PET predicted the DFS in patients with stage I NSCLC after SBRT.
AIMS: Stereotactic body radiotherapy (SBRT) is commonly considered an important treatment option for patients with stage I non-small cell lung cancer (NSCLC) who have contraindications for surgery or refuse surgery. Many studies have reported that the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) of the primary tumor has prognostic value for resected NSCLC. The purpose of this study was to determine whether SUVmax is a predictor of disease-free survival (DFS) in patients with stage I NSCLC after SBRT. METHODS: In all patients, the diagnosis was pathologically or cytologically confirmed. The prescription dose was 48 Gy in four fractions at the isocenter. FDG-PET was performed before SBRT. RESULTS: Twenty-nine patients were enrolled in this study. The median follow-up period was 14 months (range, 2-56 months). Regional lymph node metastasis and distant metastasis were observed in 5 (17%) and 2 (7%), respectively. The median SUVmax was 5.6 (range, 2.2-22.0). DFS at 2 years was significantly different between the low SUVmax (<8.0) and high SUVmax (≥8.0) groups (85 versus 17%). In univariate analysis, SUVmax and gross tumor volume were significantly correlated with DFS. Multivariate analysis included variables with P-values <0.20 and showed that only SUVmax was significantly correlated with DFS. CONCLUSION: Pretreatment SUVmax on FDG-PET predicted the DFS in patients with stage I NSCLC after SBRT.
Authors: Catharina M L Zegers; Wouter van Elmpt; Bart Reymen; Aniek J G Even; Esther G C Troost; Michel C Ollers; Frank J P Hoebers; Ruud M A Houben; Jonas Eriksson; Albert D Windhorst; Felix M Mottaghy; Dirk De Ruysscher; Philippe Lambin Journal: Clin Cancer Res Date: 2014-10-14 Impact factor: 12.531
Authors: Yoo-Kang Kwak; Hee Hyun Park; Kyu Hye Choi; Eun Young Park; Soo Yoon Sung; Sea-Won Lee; Ji Hyun Hong; Hyo Chun Lee; Ie Ryung Yoo; Yeon Sil Kim Journal: Cancer Res Treat Date: 2019-05-17 Impact factor: 4.679