BACKGROUND: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). MATERIALS AND METHODS: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). RESULTS: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). CONCLUSIONS: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.
BACKGROUND: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). MATERIALS AND METHODS: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). RESULTS: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). CONCLUSIONS: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.
Authors: Olena Yu Yefimenko; Yuliya O Savchenko; Tetyana M Falalyeyeva; Tetyana V Beregova; Nadiya M Zholobak; Mykola Ya Spivak; Oleksandr B Shcherbakov; Rostyslav V Bubnov Journal: EPMA J Date: 2015-03-11 Impact factor: 6.543
Authors: Anastasiya V Snezhkina; George S Krasnov; Anastasiya V Lipatova; Asiya F Sadritdinova; Olga L Kardymon; Maria S Fedorova; Nataliya V Melnikova; Oleg A Stepanov; Andrew R Zaretsky; Andrey D Kaprin; Boris Y Alekseev; Alexey A Dmitriev; Anna V Kudryavtseva Journal: Oxid Med Cell Longev Date: 2016-06-28 Impact factor: 6.543
Authors: Mehrdad Zeinalian; Mehdi Eshaghi; Mohammad Reza Sharbafchi; Homayoun Naji; Sayed Mohammad Masoud Marandi; Sedigheh Asgary Journal: Int J Prev Med Date: 2016-04-01
Authors: Reema F Tayyem; Hiba A Bawadi; Ihab Shehadah; Lana M Agraib; Narmeen J Al-Awwad; Dennis D Heath; Kamal E Bani-Hani Journal: Integr Cancer Ther Date: 2015-12-01 Impact factor: 3.279
Authors: Reema F Tayyem; Hiba A Bawadi; Ihab Shehadah; Kamal E Bani-Hani; Hamed Takruri; Tareq Al-Jaberi; Dennis D Heath Journal: Asian Pac J Cancer Prev Date: 2018-01-27