Literature DB >> 2417543

Monoclonal IgM in a patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups.

A A Ilyas, R H Quarles, M C Dalakas, P H Fishman, R O Brady.   

Abstract

Monoclonal IgM kappa from a patient with polyneuropathy associated with paraproteinemia was found to bind to several polysialogangliosides. Binding of IgM to gangliosides was shown by enzyme-linked immunosorbent assay (ELISA) and by overlaying thin-layer chromatograms of human brain and peripheral nerve gangliosides with the patient's serum followed by radioiodinated goat antihuman IgM. The latter technique showed that the IgM paraprotein reacted with a number of gangliosides. In an ELISA the IgM paraprotein reacted strongly with GD2, GD3, GD1b, and GT1b, but not with GM1, GM3, and GD1a. Thus, the epitope for the patient's IgM paraprotein appears to involve the disialosyl configurations.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2417543     DOI： 10.1002/ana.410180605

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  24 in total

Review 1.  Monoclonal IgM autoantibody reactivity in M-IgM peripheral neuropathy.

Authors:  C Caudie
Journal:  Clin Rev Allergy Immunol       Date:  2000-08       Impact factor: 8.667

Review 2.  Relationship between autoantibody specificities and peripheral nervous system involvements.

Authors:  M O Jauberteau-Marchan
Journal:  Clin Rev Allergy Immunol       Date:  2000-08       Impact factor: 8.667

3.  Antibodies against disialosyl and terminal NeuNAc(alpha2-3)Gal ganglioside epitopes in acute relapsing sensory ataxic neuropathy.

Authors:  Ricard Rojas-Garcia; Eduard Gallardo; Monica Povedano; Noemi de Luna; Jordi Bruna; Candido Juarez; Jordi Diaz-Manera; Juan Antonio Martinez-Matos; Isabel Illa
Journal:  J Neurol       Date:  2008-03-17       Impact factor: 4.849

4.  Ataxic polyneuropathy and anti-Pr2 IgM kappa M proteinemia.

Authors:  M Arai; H Yoshino; Y Kusano; Y Yazaki; Y Ohnishi; T Miyatake
Journal:  J Neurol       Date:  1992-03       Impact factor: 4.849

5.  Proximal motor neuropathy, IgA paraproteinaemia and anti-myelin-associated glycoprotein reactivity.

Authors:  T Hemachudha; P Phanuphak; K Phanthumchinda; S Kasempimolporn
Journal:  Postgrad Med J       Date:  1989-09       Impact factor: 2.401

6.  Antiganglioside antibodies in toxic oil syndrome.

Authors:  C Iñguez; A Jiménez-Escrig; J Gobernado; G de Blas; M Nocito; M L del Villar; P Gonzalez-Porqué
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-07       Impact factor: 10.154

7.  Antiganglioside antibodies in the CSF of patients with motor neuron diseases and Guillain-Barré syndrome.

Authors:  C Iñiguez; A Jiménez-Escrig; J M Gobernado; M Nocito; P Gonzalez-Porque
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-04       Impact factor: 10.154

Review 8.  Antiglycolipid antibodies in peripheral neuropathy: fact or fiction?

Authors:  H J Willison
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-11       Impact factor: 10.154

9.  Human monoclonal IgM with autoantibody activity against two gangliosides (GM1 and GD1b) in a patient with motor neuron syndrome.

Authors:  M O Jauberteau; N Gualde; J L Preud'Homme; M Rigaud; R Gil; J M Vallat; N Baumann
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

10.  Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins.

Authors:  H J Willison; G Paterson; J Veitch; G Inglis; S C Barnett
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-11       Impact factor: 10.154
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.