[18F]fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates.

The mono-[(18)F]fluorination of o-carborane via nucleophilic substitution is reported. The new radiochemical transformation uses cyclotron produced [(18)F]F(-) and a carboranyl iodonium salt. Further derivatization of the (18)F-labelled carborane is achieved by formation of the C(c)-lithio salt and reaction with an aldehyde.