Literature DB >> 24175146

The role of rehabilitation following autologous chondrocyte implantation: a retrospective chart review.

Jenny L Toonstra1, Jennifer S Howard, Timothy L Uhl, Robert A English, Carl G Mattacola.   

Abstract

PURPOSE/
BACKGROUND: Clinical outcomes following autologous chondrocyte implantation (ACI) are influenced by multiple factors, including patient demographics, lesion characteristics, quality of the surgical repair, and post-operative rehabilitation. However, it is currently unknown what specific characteristics of rehabilitation have the greatest influence on clinical outcomes following ACI. The purpose of this study was to conduct a retrospective chart review of patients undergoing ACI with the intent to describe this patient population's demographics, clinical outcomes, and rehabilitation practices. This study aimed to assess the consistency of the documentation process relative to post-operative rehabilitation in order to provide information and guide initiatives for improving the quality of rehabilitation practices following ACI.
METHODS: The medical records of patients treated for chondral defect(s) of the knee who subsequently underwent the ACI procedure were retrospectively reviewed. A systematic review of medical, surgical, and rehabilitation records was performed. In addition, patient-reported outcome measures (IKDC, WOMAC, Lysholm, SF-36) recorded pre-operatively, and 3, 6, and 12 months post-operatively were extracted from an existing database.
RESULTS: 20 medical charts (35.9 ± 6.8 years; 9 male, 11 female) were systematically reviewed. The average IKDC, WOMAC, Lysholm, and SF-36 scores all improved from baseline to 3, 6 and 12 months post-operatively, with the greatest changes occurring at 6 and 12 months. There was inconsistent documentation relative to post-operative rehabilitation, including CPM use, weight-bearing progression, home-exercise compliance, and strength progressions.
CONCLUSIONS: Due to variations in the documentation process, the authors were unable to determine what specific components of rehabilitation influence the recovery process. In order to further understand how rehabilitation practices influence outcomes following ACI, specific components of the rehabilitation process must be consistently and systematically documented over time. LEVEL OF EVIDENCE: 2C.

Entities:  

Keywords:  autologous chondrocyte implantation; chart review; clinical outcome; rehabilitation

Year:  2013        PMID: 24175146      PMCID: PMC3811727     

Source DB:  PubMed          Journal:  Int J Sports Phys Ther        ISSN: 2159-2896


  46 in total

1.  A comparison of two time intervals for test-retest reliability of health status instruments.

Authors:  Robert G Marx; Alia Menezes; Lois Horovitz; Edward C Jones; Russell F Warren
Journal:  J Clin Epidemiol       Date:  2003-08       Impact factor: 6.437

2.  Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee.

Authors:  Mininder S Kocher; J Richard Steadman; Karen K Briggs; William I Sterett; Richard J Hawkins
Journal:  J Bone Joint Surg Am       Date:  2004-06       Impact factor: 5.284

3.  Who is the ideal candidate for autologous chondrocyte implantation?

Authors:  S P Krishnan; J A Skinner; W Bartlett; R W J Carrington; A M Flanagan; T W R Briggs; G Bentley
Journal:  J Bone Joint Surg Br       Date:  2006-01

Review 4.  Autologous chondrocyte implantation postoperative care and rehabilitation: science and practice.

Authors:  Karen Hambly; Vladimir Bobic; Barbara Wondrasch; Dieter Van Assche; Stefan Marlovits
Journal:  Am J Sports Med       Date:  2006-01-25       Impact factor: 6.202

Review 5.  Treatment of full-thickness chondral defects in the knee with autologous chondrocyte implantation.

Authors:  Scott D Gillogly; Thomas H Myers; Michael M Reinold
Journal:  J Orthop Sports Phys Ther       Date:  2006-10       Impact factor: 4.751

6.  A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.

Authors:  Rimtautas Gudas; Romas J Kalesinskas; Vytautas Kimtys; Edgaras Stankevicius; Vytautas Toliusis; Giedrius Bernotavicius; Alfredas Smailys
Journal:  Arthroscopy       Date:  2005-09       Impact factor: 4.772

Review 7.  Rehabilitation after autologous chondrocyte implantation in athletes.

Authors:  Shane J Nho; Michael J Pensak; Daniel A Seigerman; Brian J Cole
Journal:  Clin Sports Med       Date:  2010-04       Impact factor: 2.182

8.  Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters.

Authors:  Johan Vanlauwe; Daniel B F Saris; Jan Victor; Karl Fredrik Almqvist; Johan Bellemans; Frank P Luyten
Journal:  Am J Sports Med       Date:  2011-09-09       Impact factor: 6.202

9.  Two- to 9-year outcome after autologous chondrocyte transplantation of the knee.

Authors:  L Peterson; T Minas; M Brittberg; A Nilsson; E Sjögren-Jansson; A Lindahl
Journal:  Clin Orthop Relat Res       Date:  2000-05       Impact factor: 4.176

10.  Experimental study on the repair of full thickness articular cartilage defects: effects of varying periods of continuous passive motion, cage activity, and immobilization.

Authors:  T Shimizu; T Videman; K Shimazaki; V Mooney
Journal:  J Orthop Res       Date:  1987       Impact factor: 3.494

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  1 in total

1.  Consensus on Rehabilitation Guidelines among Orthopedic Surgeons in the United States following Use of Third-Generation Articular Cartilage Repair (MACI) for Treatment of Knee Cartilage Lesions.

Authors:  David C Flanigan; Seth L Sherman; Brian Chilelli; Wayne Gersoff; Deryk Jones; Cassandra A Lee; Alison Toth; Caryn Cramer; Victor Zaporojan; James Carey
Journal:  Cartilage       Date:  2020-10-30       Impact factor: 3.117

  1 in total

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