Literature DB >> 24174318

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

Julhash U Kazi1, Nuzhat N Kabir, Lars Rönnstrand.   

Abstract

Protein kinase C (PKC) belongs to a family of ten serine/threonine protein kinases encoded by nine genes. This family of proteins plays critical roles in signal transduction which results in cell proliferation, survival, differentiation and apoptosis. Due to differential subcellular localization and tissue distribution, each member displays distinct signaling characteristics. In this review, we have summarized the roles of PKC family members in chronic lymphocytic leukemia (CLL). CLL is a heterogeneous hematological disorder with survival ranging from months to decades. PKC isoforms are differentially expressed in CLL and play critical roles in CLL pathogenesis. Thus, isoform-specific PKC inhibitors may be an attractive option for CLL treatment.

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Year:  2013        PMID： 24174318     DOI： 10.1007/s12032-013-0757-7

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  77 in total

1.  Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL.

Authors:  I Ringshausen; M Oelsner; K Weick; C Bogner; C Peschel; T Decker
Journal:  Leukemia       Date:  2006-03       Impact factor: 11.528

2.  Protein kinase C expression is deregulated in chronic lymphocytic leukemia.

Authors:  Nuzhat N Kabir; Lars Rönnstrand; Julhash U Kazi
Journal:  Leuk Lymphoma       Date:  2013-02-16

3.  Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.

Authors:  Elke Heiss; Kristina Masson; Christina Sundberg; Malin Pedersen; Jianmin Sun; Susanne Bengtsson; Lars Rönnstrand
Journal:  Blood       Date:  2006-05-09       Impact factor: 22.113

4.  PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

Authors:  S W Kang; M I Wahl; J Chu; J Kitaura; Y Kawakami; R M Kato; R Tabuchi; A Tarakhovsky; T Kawakami; C W Turck; O N Witte; D J Rawlings
Journal:  EMBO J       Date:  2001-10-15       Impact factor: 11.598

5.  Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.

Authors:  B Scaglione-Sewell; C Abraham; M Bissonnette; S F Skarosi; J Hart; N O Davidson; R K Wali; B H Davis; M Sitrin; T A Brasitus
Journal:  Cancer Res       Date:  1998-03-01       Impact factor: 12.701

6.  Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

Authors:  B A Hocevar; A P Fields
Journal:  J Biol Chem       Date:  1991-01-05       Impact factor: 5.157

7.  Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

Authors:  Ingo Ringshausen; Folker Schneller; Christian Bogner; Susanne Hipp; Justus Duyster; Christian Peschel; Thomas Decker
Journal:  Blood       Date:  2002-07-12       Impact factor: 22.113

8.  Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein.

Authors:  N Sakai; K Sasaki; N Ikegaki; Y Shirai; Y Ono; N Saito
Journal:  J Cell Biol       Date:  1997-12-15       Impact factor: 10.539

9.  Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells.

Authors:  M Leirdal; M Sioud
Journal:  Br J Cancer       Date:  1999-07       Impact factor: 7.640

10.  Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.

Authors:  Julhash U Kazi; Lars Rönnstrand
Journal:  PLoS One       Date:  2012-12-31       Impact factor: 3.240
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  20 in total

1.  Signal Transduction in Immune Cells and Protein Kinases.

Authors:  Monica Neagu; Carolina Constantin
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 2.  Grb10 is a dual regulator of receptor tyrosine kinase signaling.

Authors:  Nuzhat N Kabir; Julhash U Kazi
Journal:  Mol Biol Rep       Date:  2014-01-14       Impact factor: 2.316

Review 3.  Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

Authors:  Julhash U Kazi; Nuzhat N Kabir; Lars Rönnstrand
Journal:  Cell Mol Life Sci       Date:  2015-03-13       Impact factor: 9.261

Review 4.  SOCS6 is a selective suppressor of receptor tyrosine kinase signaling.

Authors:  Nuzhat N Kabir; Jianmin Sun; Lars Rönnstrand; Julhash U Kazi
Journal:  Tumour Biol       Date:  2014-08-30

Review 5.  Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date.

Authors:  Kyle Crassini; Stephen P Mulligan; O Giles Best
Journal:  World J Clin Cases       Date:  2015-08-16       Impact factor: 1.337

Review 6.  SOCS proteins in regulation of receptor tyrosine kinase signaling.

Authors:  Julhash U Kazi; Nuzhat N Kabir; Amilcar Flores-Morales; Lars Rönnstrand
Journal:  Cell Mol Life Sci       Date:  2014-04-05       Impact factor: 9.261

7.  Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells.

Authors:  A Rodríguez-Lirio; G Pérez-Yarza; M R Fernández-Suárez; E Alonso-Tejerina; M D Boyano; A Asumendi
Journal:  Leuk Res Treatment       Date:  2015-11-25

8.  Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors.

Authors:  Emanuela Corsini; Valentina Galbiati; Antonella Pinto; Annalisa Davin; Letizia Polito; Antonio Guaita; Marco Racchi
Journal:  Oncotarget       Date:  2015-03-30

Review 9.  Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia development.

Authors:  André L Mencalha; Stephany Corrêa; Eliana Abdelhay
Journal:  Onco Targets Ther       Date:  2014-07-08       Impact factor: 4.147

Review 10.  Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer.

Authors:  Mohammad Mojtaba Sadeghi; Mohamed F Salama; Yusuf A Hannun
Journal:  Int J Mol Sci       Date:  2021-05-24       Impact factor: 5.923
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