BACKGROUND: The purpose of this study was to compare outcomes among patients treated by intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for head and neck cancer according to the margins used to expand the clinical target volume (CTV) to create a planning target volume (PTV). METHODS: Three hundred sixty-seven consecutive patients were treated with IMRT for squamous cell carcinoma of the head and neck. The first 103 patients were treated with 5-mm CTV-to-PTV margins. The subsequent 264 patients were treated using reduced (3 mm) margins. RESULTS: The 3-year locoregional control for patients treated using 5-mm and 3-mm CTV-to-PTV margins, respectively, was 78% and 80% (p = .75). The incidence of gastrostomy-tube dependence at 1 year was 10% and 3%, respectively (p = .001). The incidence of posttreatment esophageal stricture was 14% and 7%, respectively (p = .01). CONCLUSION: The use of reduced (3 mm) CTV-to-PTV margins was associated with reduced late toxicity while maintaining locoregional control.
BACKGROUND: The purpose of this study was to compare outcomes among patients treated by intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for head and neck cancer according to the margins used to expand the clinical target volume (CTV) to create a planning target volume (PTV). METHODS: Three hundred sixty-seven consecutive patients were treated with IMRT for squamous cell carcinoma of the head and neck. The first 103 patients were treated with 5-mm CTV-to-PTV margins. The subsequent 264 patients were treated using reduced (3 mm) margins. RESULTS: The 3-year locoregional control for patients treated using 5-mm and 3-mm CTV-to-PTV margins, respectively, was 78% and 80% (p = .75). The incidence of gastrostomy-tube dependence at 1 year was 10% and 3%, respectively (p = .001). The incidence of posttreatment esophageal stricture was 14% and 7%, respectively (p = .01). CONCLUSION: The use of reduced (3 mm) CTV-to-PTV margins was associated with reduced late toxicity while maintaining locoregional control.
Authors: Reto Bertolini; Christa Meyenberger; Paul Martin Putora; Franziska Albrecht; Martina Anja Broglie; Sandro J Stoeckli; Michael Christian Sulz Journal: World J Gastroenterol Date: 2016-02-21 Impact factor: 5.742
Authors: Sebastien A A Gros; Anand P Santhanam; Alec M Block; Bahman Emami; Brian H Lee; Cara Joyce Journal: Front Oncol Date: 2022-06-30 Impact factor: 5.738
Authors: Shane Mesko; He Wang; Samuel Tung; Congjun Wang; Dario Pasalic; Bhavana V Chapman; Amy C Moreno; Jay P Reddy; Adam S Garden; David I Rosenthal; G Brandon Gunn; Steven J Frank; Clifton D Fuller; William Morrison; Jack Phan Journal: Int J Radiat Oncol Biol Phys Date: 2019-09-30 Impact factor: 7.038
Authors: Olgun Elicin; Dario Terribilini; Mohamed Shelan; Werner Volken; Etienne Mathier; Alan Dal Pra; Daniel M Aebersold; Michael K Fix; Peter Manser Journal: Radiat Oncol Date: 2017-06-20 Impact factor: 3.481