Literature DB >> 2417392

Human lymphocyte responses to Plasmodium falciparum merozoite antigens. A functional assay of protective immunity?

J J Ballet, P Druilhe, I Vasconcelos, C Schmitt, M Agrapart, D Frommel.   

Abstract

Merozoites obtained from cutaneous cultures of Plasmodium falciparum were used as antigen for an in vitro lymphocyte assay. Antigen specific proliferative responses were observed with lymphocytes from individuals with long-standing immunity to P. falciparum. Donors whose last P. falciparum challenge occurred within the year preceding the assay exhibited lymphocyte responses significantly higher than those from donors whose infection was more remote. This suggests that a lymphocyte dependent assay may relate to the protective status of the donor.

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Year:  1985        PMID: 2417392     DOI: 10.1016/0035-9203(85)90076-8

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN: 0035-9203            Impact factor:   2.184


  4 in total

1.  Interactions of CD4+ and CD8+ human T lymphocytes from malaria-unprimed donors with Plasmodium falciparum schizont stage.

Authors:  C Roussilhon; M Agrapart; C Behr; P Dubois; J J Ballet
Journal:  J Clin Microbiol       Date:  1989-11       Impact factor: 5.948

2.  Epidemiological correlation between levels of antibodies promoting merozoite phagocytosis of Plasmodium falciparum and malaria-immune status.

Authors:  P Druilhe; S Khusmith
Journal:  Infect Immun       Date:  1987-04       Impact factor: 3.441

3.  Cellular immune responses to Plasmodium falciparum antigens in Gambian children during and after an acute attack of falciparum malaria.

Authors:  E M Riley; G Andersson; L N Otoo; S Jepsen; B M Greenwood
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330

4.  Cell-mediated immune responses to Plasmodium falciparum antigens in adult Gambians.

Authors:  E M Riley; S Jepsen; G Andersson; L N Otoo; B M Greenwood
Journal:  Clin Exp Immunol       Date:  1988-03       Impact factor: 4.330

  4 in total

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