Pascale Amate1, Cyrille Huchon, Anne Lucie Dessapt, Chérazade Bensaid, Jacques Medioni, Marie-Aude Le Frère Belda, Anne-Sophie Bats, Fabrice R Lécuru. 1. *Service de Chirurgie Cancérologique Gynécologique et du Sein, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; †Service de Gynécologie & Obstétrique, CHI Poissy-St-Germain, Poissy, France; ‡Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; §Service d'Oncologie Médicale, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; ∥Service d'Anatamopathologie, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; ¶INSERM UMR-S 747, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; and #Equipe d'accueil EA 7285 "Risques, cliniques et sécurité en santé des femmes et en sante périnatale," Université Versailles-Saint-Quentin en Yvelines, 78000 Versailles, France.
Abstract
INTRODUCTION: Improved knowledge of recurrence sites after contemporary surgical management of ovarian cancer is needed. MATERIAL AND METHODS: We retrospectively reviewed consecutive patients managed for epithelial ovarian or tubal cancer with surgery and platinum-based chemotherapy between January 1, 2005, and December 31, 2009, in a tertiary teaching hospital. The site of first recurrence was recorded. Univariate analysis was performed to identify factors associated with site-specific recurrence. Overall survival and progression-free survival were computed using the Kaplan-Meier method, and log-rank tests were performed to assess the impact on survival of the variables of interest. RESULTS: Recurrences were noted in 3 (20%) of 15 International Federation of Gynecologists and Obstetricians stage I to IIa patients and 36 (62.1%) of 58 International Federation of Gynecologists and Obstetricians IIb to IV patients, and the median progression-free survival was 21.6 (2.5-71) and 19.3 (1.8-67.6) months, respectively. In the advanced-disease group, 75% of recurrences involved the peritoneum and 40% were confined to the peritoneum; peritoneal recurrences developed at both treated and untreated sites. Peritoneal recurrence was associated with greater initial peritoneal involvement (Sugarbaker score, 12.1 ± 8.2 vs 7.1 ± 7.4; P = 0.01) and residual postoperative tumor. Nodal recurrences were noted in 38% of all recurrences, usually in combination with peritoneal recurrence and in the abdominal territories. Isolated distant metastasis was a rare mode of recurrence (8%). CONCLUSIONS: The peritoneum is the main recurrence site in both early and advanced ovarian cancer. Initial disease spread and extent of surgery are associated with the recurrence risk. This article supports the view that more attention should be directed toward extensive treatment of the peritoneum.
INTRODUCTION: Improved knowledge of recurrence sites after contemporary surgical management of ovarian cancer is needed. MATERIAL AND METHODS: We retrospectively reviewed consecutive patients managed for epithelial ovarian or tubal cancer with surgery and platinum-based chemotherapy between January 1, 2005, and December 31, 2009, in a tertiary teaching hospital. The site of first recurrence was recorded. Univariate analysis was performed to identify factors associated with site-specific recurrence. Overall survival and progression-free survival were computed using the Kaplan-Meier method, and log-rank tests were performed to assess the impact on survival of the variables of interest. RESULTS: Recurrences were noted in 3 (20%) of 15 International Federation of Gynecologists and Obstetricians stage I to IIa patients and 36 (62.1%) of 58 International Federation of Gynecologists and Obstetricians IIb to IV patients, and the median progression-free survival was 21.6 (2.5-71) and 19.3 (1.8-67.6) months, respectively. In the advanced-disease group, 75% of recurrences involved the peritoneum and 40% were confined to the peritoneum; peritoneal recurrences developed at both treated and untreated sites. Peritoneal recurrence was associated with greater initial peritoneal involvement (Sugarbaker score, 12.1 ± 8.2 vs 7.1 ± 7.4; P = 0.01) and residual postoperative tumor. Nodal recurrences were noted in 38% of all recurrences, usually in combination with peritoneal recurrence and in the abdominal territories. Isolated distant metastasis was a rare mode of recurrence (8%). CONCLUSIONS: The peritoneum is the main recurrence site in both early and advanced ovarian cancer. Initial disease spread and extent of surgery are associated with the recurrence risk. This article supports the view that more attention should be directed toward extensive treatment of the peritoneum.
Authors: Deepa Magge; Lekshmi Ramalingam; Yongli Shuai; Robert P Edwards; James F Pingpank; Steven S Ahrendt; Matthew P Holtzman; Herbert J Zeh; David L Bartlett; Haroon A Choudry Journal: J Surg Oncol Date: 2017-06-19 Impact factor: 3.454
Authors: Marina Stasenko; Paulina Cybulska; Noah Feit; Vicky Makker; Jason Konner; Roisin E O'Cearbhaill; Kaled M Alektiar; Kathryn Beal; Ginger J Gardner; Kara C Long Roche; Yukio Sonoda; Dennis S Chi; Oliver Zivanovic; Mario M Leitao; Karen A Cadoo; William P Tew Journal: Gynecol Oncol Date: 2019-05-18 Impact factor: 5.482
Authors: Shanyang He; Gang Niu; Jianhong Shang; Yalan Deng; Zhiyong Wan; Cai Zhang; Zeshan You; Hongwei Shen Journal: J Exp Clin Cancer Res Date: 2017-10-04